Summary of Study ST002661

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001020. The data can be accessed directly via it's Project DOI: 10.21228/M8V97D This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

Study ID	ST002661
Study Title	MoTrPAC: Endurance exercise training study in young adult rats, Tissue:Heart - Targeted Acyl-CoA
Study Summary	The goal of the endurance exercise training study in young adult rats (internal code: PASS1B-06) was to perform exercise training studies in adult (6 month) F344 rats, and from these rats collect as many tissues as feasible in order to provide high quality samples for detailed analysis by chemical analysis sites. Tissues were collected from 10-12 rats sedentary control rats concurrent with the collection of the 8-week training groups. The 8-week training group and controls were from the same cohort and same age at euthanasia (either 8). For the older age group, an additional set of controls (n=5-6) were collected with the 1-2 week training group. Rats were either sedentary or underwent an exercise training program. Rats were exercised on the rodent treadmill 5 days per week using a progressive training protocol designed to exercise the rats at approximately 70% of VO2max as outlined in the Table on the next page. Training was performed no earlier than 10:00 am and no later than 5:00 pm over 5 consecutive days per week. Training was initiated with the treadmill set at 70% of VO2 max (see tables) and 5 degrees grade for 20 minutes. The duration of exercise was increased by one minute each day until day 31 of training (start of week 7), when a duration of 50 min was reached. Speed and grade of each training session increased in larger increments due to treadmill parameters. The highest intensity and duration of training began on day 31. This intensity was maintained for the final 10 days of the protocol to ensure steady state had been achieved. If any rats were unable to perform at least 4 days of training per week they were removed from the study and euthanized. It is important to note that the starting treadmill speed varied depending on the sex and age of the rat. The initial and maximum speeds were based on VO2max measurements obtained during the pre-training testing of the compliant rats. Rats assigned to the control group followed a schedule similar to the training group. They were placed in one lane on the treadmill for 15 minutes/day, 5 days per week. The treadmill was set at 0 m/min at an incline that corresponded to the incline being used by the training group.
Institute	Duke University
Department	Duke Molecular Physiology Institute
Laboratory	Metabolomics Core Laboratory
Last Name	Newgard
First Name	Christopher
Address	300 N Duke St, Durham, NC 27701
Email	chris.newgard@duke.edu
Phone	(919) 668-6059
Submit Date	2023-04-25
Raw Data Available	Yes
Raw Data File Type(s)	TBD
Analysis Type Detail	LC-MS
Release Date	2023-10-06
Release Version	1

Select appropriate tab below to view additional metadata details:

Factors:

Subject type: Mammal; Subject species: Rattus norvegicus (Factor headings shown in green)

mb_sample_id	local_sample_id	Group	Timepoint	Sex
SA264160	90266015810	Control	8 weeks of training or control time	Female
SA264161	90248015810	Control	8 weeks of training or control time	Female
SA264162	90245015810	Control	8 weeks of training or control time	Female
SA264163	90252015810	Control	8 weeks of training or control time	Female
SA264164	90265015810	Control	8 weeks of training or control time	Female
SA264165	90237015810	Control	8 weeks of training or control time	Male
SA264166	90232015810	Control	8 weeks of training or control time	Male
SA264167	90217015810	Control	8 weeks of training or control time	Male
SA264168	90239015810	Control	8 weeks of training or control time	Male
SA264169	90229015810	Control	8 weeks of training or control time	Male
SA264170	80022815818_3	QC-ExternalStandard	0 hour	-
SA264171	80023825818_3	QC-ExternalStandard	0 hour	-
SA264172	80023825818_2	QC-ExternalStandard	0 hour	-
SA264173	80022815818_1	QC-ExternalStandard	0 hour	-
SA264174	80022815818_2	QC-ExternalStandard	0 hour	-
SA264175	80023825818_4	QC-ExternalStandard	0 hour	-
SA264176	80022815818_4	QC-ExternalStandard	0 hour	-
SA264177	80023825818_1	QC-ExternalStandard	0 hour	-
SA264178	90567015810	Training	1 week of training or control time	Female
SA264179	90560015810	Training	1 week of training or control time	Female
SA264180	90571015810	Training	1 week of training or control time	Female
SA264181	90564015810	Training	1 week of training or control time	Female
SA264182	90559015810	Training	1 week of training or control time	Female
SA264183	90426015810	Training	1 week of training or control time	Male
SA264184	90423015810	Training	1 week of training or control time	Male
SA264185	90421015810	Training	1 week of training or control time	Male
SA264186	90430015810	Training	1 week of training or control time	Male
SA264187	90422015810	Training	1 week of training or control time	Male
SA264188	90581015810	Training	2 weeks of training	Female
SA264189	90578015810	Training	2 weeks of training	Female
SA264190	90587015810	Training	2 weeks of training	Female
SA264191	90576015810	Training	2 weeks of training	Female
SA264192	90585015810	Training	2 weeks of training	Female
SA264193	90444015810	Training	2 weeks of training	Male
SA264194	90439015810	Training	2 weeks of training	Male
SA264195	90450015810	Training	2 weeks of training	Male
SA264196	90441015810	Training	2 weeks of training	Male
SA264197	90449015810	Training	2 weeks of training	Male
SA264198	90416015810	Training	4 weeks of training	Female
SA264199	90412015810	Training	4 weeks of training	Female
SA264200	90420015810	Training	4 weeks of training	Female
SA264201	90410015810	Training	4 weeks of training	Female
SA264202	90406015810	Training	4 weeks of training	Female
SA264203	90289015810	Training	4 weeks of training	Male
SA264204	90281015810	Training	4 weeks of training	Male
SA264205	90283015810	Training	4 weeks of training	Male
SA264206	90280015810	Training	4 weeks of training	Male
SA264207	90292015810	Training	4 weeks of training	Male
SA264208	90254015810	Training	8 weeks of training or control time	Female
SA264209	90267015810	Training	8 weeks of training or control time	Female
SA264210	90258015810	Training	8 weeks of training or control time	Female
SA264211	90259015810	Training	8 weeks of training or control time	Female
SA264212	90251015810	Training	8 weeks of training or control time	Female
SA264213	90225015810	Training	8 weeks of training or control time	Male
SA264214	90222015810	Training	8 weeks of training or control time	Male
SA264215	90223015810	Training	8 weeks of training or control time	Male
SA264216	90227015810	Training	8 weeks of training or control time	Male
SA264217	90218015810	Training	8 weeks of training or control time	Male

Showing results 1 to 58 of 58

Showing results 1 to 58 of 58