Summary of Study ST002662

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001020. The data can be accessed directly via it's Project DOI: 10.21228/M8V97D This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

Study ID	ST002662
Study Title	MoTrPAC: Endurance exercise training study in young adult rats, Tissue:Liver - Targeted Acyl-CoA
Study Summary	The goal of the endurance exercise training study in young adult rats (internal code: PASS1B-06) was to perform exercise training studies in adult (6 month) F344 rats, and from these rats collect as many tissues as feasible in order to provide high quality samples for detailed analysis by chemical analysis sites. Tissues were collected from 10-12 rats sedentary control rats concurrent with the collection of the 8-week training groups. The 8-week training group and controls were from the same cohort and same age at euthanasia (either 8). For the older age group, an additional set of controls (n=5-6) were collected with the 1-2 week training group. Rats were either sedentary or underwent an exercise training program. Rats were exercised on the rodent treadmill 5 days per week using a progressive training protocol designed to exercise the rats at approximately 70% of VO2max as outlined in the Table on the next page. Training was performed no earlier than 10:00 am and no later than 5:00 pm over 5 consecutive days per week. Training was initiated with the treadmill set at 70% of VO2 max (see tables) and 5 degrees grade for 20 minutes. The duration of exercise was increased by one minute each day until day 31 of training (start of week 7), when a duration of 50 min was reached. Speed and grade of each training session increased in larger increments due to treadmill parameters. The highest intensity and duration of training began on day 31. This intensity was maintained for the final 10 days of the protocol to ensure steady state had been achieved. If any rats were unable to perform at least 4 days of training per week they were removed from the study and euthanized. It is important to note that the starting treadmill speed varied depending on the sex and age of the rat. The initial and maximum speeds were based on VO2max measurements obtained during the pre-training testing of the compliant rats. Rats assigned to the control group followed a schedule similar to the training group. They were placed in one lane on the treadmill for 15 minutes/day, 5 days per week. The treadmill was set at 0 m/min at an incline that corresponded to the incline being used by the training group.
Institute	Duke University
Department	Duke Molecular Physiology Institute
Laboratory	Metabolomics Core Laboratory
Last Name	Newgard
First Name	Christopher
Address	300 N Duke St, Durham, NC 27701
Email	chris.newgard@duke.edu
Phone	(919) 668-6059
Submit Date	2023-04-25
Raw Data Available	Yes
Raw Data File Type(s)	TBD
Analysis Type Detail	LC-MS
Release Date	2023-10-06
Release Version	1

Select appropriate tab below to view additional metadata details:

Factors:

Subject type: Mammal; Subject species: Rattus norvegicus (Factor headings shown in green)

mb_sample_id	local_sample_id	Group	Timepoint	Sex
SA264218	90248016811	Control	8 weeks of training or control time	Female
SA264219	90252016811	Control	8 weeks of training or control time	Female
SA264220	90266016811	Control	8 weeks of training or control time	Female
SA264221	90245016811	Control	8 weeks of training or control time	Female
SA264222	90265016811	Control	8 weeks of training or control time	Female
SA264223	90229016811	Control	8 weeks of training or control time	Male
SA264224	90232016811	Control	8 weeks of training or control time	Male
SA264225	90217016811	Control	8 weeks of training or control time	Male
SA264226	90239016811	Control	8 weeks of training or control time	Male
SA264227	90237016811	Control	8 weeks of training or control time	Male
SA264228	80010816802_1	QC-ExternalStandard	0 hour	-
SA264229	80011826802_2	QC-ExternalStandard	0 hour	-
SA264230	80010816802_3	QC-ExternalStandard	0 hour	-
SA264231	80011826802_1	QC-ExternalStandard	0 hour	-
SA264232	80010816802_4	QC-ExternalStandard	0 hour	-
SA264233	80011826802_3	QC-ExternalStandard	0 hour	-
SA264234	80010816802_2	QC-ExternalStandard	0 hour	-
SA264235	80011826802_4	QC-ExternalStandard	0 hour	-
SA264236	90571016811	Training	1 week of training or control time	Female
SA264237	90559016811	Training	1 week of training or control time	Female
SA264238	90567016811	Training	1 week of training or control time	Female
SA264239	90564016811	Training	1 week of training or control time	Female
SA264240	90560016811	Training	1 week of training or control time	Female
SA264241	90430016811	Training	1 week of training or control time	Male
SA264242	90423016811	Training	1 week of training or control time	Male
SA264243	90426016811	Training	1 week of training or control time	Male
SA264244	90421016811	Training	1 week of training or control time	Male
SA264245	90422016811	Training	1 week of training or control time	Male
SA264246	90587016811	Training	2 weeks of training	Female
SA264247	90578016811	Training	2 weeks of training	Female
SA264248	90581016811	Training	2 weeks of training	Female
SA264249	90576016811	Training	2 weeks of training	Female
SA264250	90585016811	Training	2 weeks of training	Female
SA264251	90441016811	Training	2 weeks of training	Male
SA264252	90450016811	Training	2 weeks of training	Male
SA264253	90439016811	Training	2 weeks of training	Male
SA264254	90449016811	Training	2 weeks of training	Male
SA264255	90444016811	Training	2 weeks of training	Male
SA264256	90410016811	Training	4 weeks of training	Female
SA264257	90420016811	Training	4 weeks of training	Female
SA264258	90406016811	Training	4 weeks of training	Female
SA264259	90416016811	Training	4 weeks of training	Female
SA264260	90412016811	Training	4 weeks of training	Female
SA264261	90292016811	Training	4 weeks of training	Male
SA264262	90280016811	Training	4 weeks of training	Male
SA264263	90283016811	Training	4 weeks of training	Male
SA264264	90289016811	Training	4 weeks of training	Male
SA264265	90281016811	Training	4 weeks of training	Male
SA264266	90267016811	Training	8 weeks of training or control time	Female
SA264267	90259016811	Training	8 weeks of training or control time	Female
SA264268	90254016811	Training	8 weeks of training or control time	Female
SA264269	90251016811	Training	8 weeks of training or control time	Female
SA264270	90258016811	Training	8 weeks of training or control time	Female
SA264271	90227016811	Training	8 weeks of training or control time	Male
SA264272	90222016811	Training	8 weeks of training or control time	Male
SA264273	90225016811	Training	8 weeks of training or control time	Male
SA264274	90223016811	Training	8 weeks of training or control time	Male
SA264275	90218016811	Training	8 weeks of training or control time	Male

Showing results 1 to 58 of 58

Showing results 1 to 58 of 58