Summary of Study ST002664

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001020. The data can be accessed directly via it's Project DOI: 10.21228/M8V97D This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

Study ID	ST002664
Study Title	MoTrPAC: Endurance exercise training study in young adult rats, Tissue:Colon - Untargeted HILIC-Positive
Study Summary	The goal of the endurance exercise training study in young adult rats (internal code: PASS1B-06) was to perform exercise training studies in adult (6 month) F344 rats, and from these rats collect as many tissues as feasible in order to provide high quality samples for detailed analysis by chemical analysis sites. Tissues were collected from 10-12 rats sedentary control rats concurrent with the collection of the 8-week training groups. The 8-week training group and controls were from the same cohort and same age at euthanasia (either 8). For the older age group, an additional set of controls (n=5-6) were collected with the 1-2 week training group. Rats were either sedentary or underwent an exercise training program. Rats were exercised on the rodent treadmill 5 days per week using a progressive training protocol designed to exercise the rats at approximately 70% of VO2max as outlined in the Table on the next page. Training was performed no earlier than 10:00 am and no later than 5:00 pm over 5 consecutive days per week. Training was initiated with the treadmill set at 70% of VO2 max (see tables) and 5 degrees grade for 20 minutes. The duration of exercise was increased by one minute each day until day 31 of training (start of week 7), when a duration of 50 min was reached. Speed and grade of each training session increased in larger increments due to treadmill parameters. The highest intensity and duration of training began on day 31. This intensity was maintained for the final 10 days of the protocol to ensure steady state had been achieved. If any rats were unable to perform at least 4 days of training per week they were removed from the study and euthanized. It is important to note that the starting treadmill speed varied depending on the sex and age of the rat. The initial and maximum speeds were based on VO2max measurements obtained during the pre-training testing of the compliant rats. Rats assigned to the control group followed a schedule similar to the training group. They were placed in one lane on the treadmill for 15 minutes/day, 5 days per week. The treadmill was set at 0 m/min at an incline that corresponded to the incline being used by the training group.
Institute	Broad Institute of MIT and Harvard
Department	Metabolomics Platform
Laboratory	Clish
Last Name	Clish
First Name	Clary
Address	415 Main St, Cambridge, MA 02142
Email	clary@broadinstitute.org
Phone	(617) 714-7654
Submit Date	2023-05-02
Raw Data Available	Yes
Raw Data File Type(s)	TBD
Analysis Type Detail	LC-MS
Release Date	2023-10-06
Release Version	1

Select appropriate tab below to view additional metadata details:

Factors:

Subject type: Mammal; Subject species: Rattus norvegicus (Factor headings shown in green)

mb_sample_id	local_sample_id	Group	Timepoint	Sex
SA264331	90245016103	Control	8 weeks of training or control time	Female
SA264332	90248016103	Control	8 weeks of training or control time	Female
SA264333	90252016103	Control	8 weeks of training or control time	Female
SA264334	90266016103	Control	8 weeks of training or control time	Female
SA264335	90265016103	Control	8 weeks of training or control time	Female
SA264336	90237016103	Control	8 weeks of training or control time	Male
SA264337	90229016103	Control	8 weeks of training or control time	Male
SA264338	90239016103	Control	8 weeks of training or control time	Male
SA264339	90217016103	Control	8 weeks of training or control time	Male
SA264340	90232016103	Control	8 weeks of training or control time	Male
SA264341	QC_PREFA03	QC-DriftCorrection	0 hour	-
SA264342	QC_PREFA01	QC-DriftCorrection	0 hour	-
SA264343	QC_PREFA02	QC-DriftCorrection	0 hour	-
SA264344	QC_PREFA04	QC-DriftCorrection	0 hour	-
SA264345	QC_PREFB02	QC-Pooled	0 hour	-
SA264346	QC_PREFB04	QC-Pooled	0 hour	-
SA264347	QC_PREFB01	QC-Pooled	0 hour	-
SA264348	QC_PREFB03	QC-Pooled	0 hour	-
SA264349	QC_Sed02	QC-Reference	0 hour	-
SA264350	QC_IPE01	QC-Reference	0 hour	-
SA264351	QC_IPE04	QC-Reference	0 hour	-
SA264352	QC_IPE03	QC-Reference	0 hour	-
SA264353	QC_Sed01	QC-Reference	0 hour	-
SA264354	QC_Sed04	QC-Reference	0 hour	-
SA264355	QC_IPE02	QC-Reference	0 hour	-
SA264356	QC_Sed03	QC-Reference	0 hour	-
SA264357	90564016103	Training	1 week of training or control time	Female
SA264358	90567016103	Training	1 week of training or control time	Female
SA264359	90559016103	Training	1 week of training or control time	Female
SA264360	90560016103	Training	1 week of training or control time	Female
SA264361	90571016103	Training	1 week of training or control time	Female
SA264362	90423016103	Training	1 week of training or control time	Male
SA264363	90426016103	Training	1 week of training or control time	Male
SA264364	90430016103	Training	1 week of training or control time	Male
SA264365	90421016103	Training	1 week of training or control time	Male
SA264366	90422016103	Training	1 week of training or control time	Male
SA264367	90578016103	Training	2 weeks of training	Female
SA264368	90587016103	Training	2 weeks of training	Female
SA264369	90581016103	Training	2 weeks of training	Female
SA264370	90585016103	Training	2 weeks of training	Female
SA264371	90576016103	Training	2 weeks of training	Female
SA264372	90449016103	Training	2 weeks of training	Male
SA264373	90444016103	Training	2 weeks of training	Male
SA264374	90439016103	Training	2 weeks of training	Male
SA264375	90450016103	Training	2 weeks of training	Male
SA264376	90441016103	Training	2 weeks of training	Male
SA264377	90406016103	Training	4 weeks of training	Female
SA264378	90420016103	Training	4 weeks of training	Female
SA264379	90410016103	Training	4 weeks of training	Female
SA264380	90412016103	Training	4 weeks of training	Female
SA264381	90416016103	Training	4 weeks of training	Female
SA264382	90280016103	Training	4 weeks of training	Male
SA264383	90281016103	Training	4 weeks of training	Male
SA264384	90289016103	Training	4 weeks of training	Male
SA264385	90292016103	Training	4 weeks of training	Male
SA264386	90283016103	Training	4 weeks of training	Male
SA264387	90251016103	Training	8 weeks of training or control time	Female
SA264388	90254016103	Training	8 weeks of training or control time	Female
SA264389	90267016103	Training	8 weeks of training or control time	Female
SA264390	90258016103	Training	8 weeks of training or control time	Female
SA264391	90259016103	Training	8 weeks of training or control time	Female
SA264392	90222016103	Training	8 weeks of training or control time	Male
SA264393	90218016103	Training	8 weeks of training or control time	Male
SA264394	90225016103	Training	8 weeks of training or control time	Male
SA264395	90227016103	Training	8 weeks of training or control time	Male
SA264396	90223016103	Training	8 weeks of training or control time	Male

Showing results 1 to 66 of 66

Showing results 1 to 66 of 66