Summary of Study ST002673

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001020. The data can be accessed directly via it's Project DOI: 10.21228/M8V97D This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

Study ID	ST002673
Study Title	MoTrPAC: Endurance exercise training study in young adult rats, Tissue:Lung - Untargeted Reversed-Phase Positive
Study Summary	The goal of the endurance exercise training study in young adult rats (internal code: PASS1B-06) was to perform exercise training studies in adult (6 month) F344 rats, and from these rats collect as many tissues as feasible in order to provide high quality samples for detailed analysis by chemical analysis sites. Tissues were collected from 10-12 rats sedentary control rats concurrent with the collection of the 8-week training groups. The 8-week training group and controls were from the same cohort and same age at euthanasia (either 8). For the older age group, an additional set of controls (n=5-6) were collected with the 1-2 week training group. Rats were either sedentary or underwent an exercise training program. Rats were exercised on the rodent treadmill 5 days per week using a progressive training protocol designed to exercise the rats at approximately 70% of VO2max as outlined in the Table on the next page. Training was performed no earlier than 10:00 am and no later than 5:00 pm over 5 consecutive days per week. Training was initiated with the treadmill set at 70% of VO2 max (see tables) and 5 degrees grade for 20 minutes. The duration of exercise was increased by one minute each day until day 31 of training (start of week 7), when a duration of 50 min was reached. Speed and grade of each training session increased in larger increments due to treadmill parameters. The highest intensity and duration of training began on day 31. This intensity was maintained for the final 10 days of the protocol to ensure steady state had been achieved. If any rats were unable to perform at least 4 days of training per week they were removed from the study and euthanized. It is important to note that the starting treadmill speed varied depending on the sex and age of the rat. The initial and maximum speeds were based on VO2max measurements obtained during the pre-training testing of the compliant rats. Rats assigned to the control group followed a schedule similar to the training group. They were placed in one lane on the treadmill for 15 minutes/day, 5 days per week. The treadmill was set at 0 m/min at an incline that corresponded to the incline being used by the training group.
Institute	University of Michigan
Department	Biomedical Research Core Facilities
Laboratory	Metabolomics core
Last Name	Burant
First Name	Charles
Address	6120 Brehm Tower,1000 Wall St., Ann Arbor, MI, 48105-5714
Email	burantc@med.umich.edu
Phone	(734) 232-0842
Submit Date	2023-05-02
Num Groups	65
Total Subjects	50
Raw Data Available	Yes
Raw Data File Type(s)	TBD
Analysis Type Detail	LC-MS
Release Date	2023-10-06
Release Version	1

Select appropriate tab below to view additional metadata details:

Factors:

Subject type: Mammal; Subject species: Rattus norvegicus (Factor headings shown in green)

mb_sample_id	local_sample_id	Group	Timepoint	Sex
SA264919	90266016606	Control	8 weeks of training or control time	Female
SA264920	90245016606	Control	8 weeks of training or control time	Female
SA264921	90248016606	Control	8 weeks of training or control time	Female
SA264922	90265016606	Control	8 weeks of training or control time	Female
SA264923	90252016606	Control	8 weeks of training or control time	Female
SA264924	90217016606	Control	8 weeks of training or control time	Male
SA264925	90229016606	Control	8 weeks of training or control time	Male
SA264926	90237016606	Control	8 weeks of training or control time	Male
SA264927	90232016606	Control	8 weeks of training or control time	Male
SA264928	90239016606	Control	8 weeks of training or control time	Male
SA264929	CS00000SB-04	QC-Blank	0 hour	-
SA264930	CS00000SB-05	QC-Blank	0 hour	-
SA264931	CS00000SB-03	QC-Blank	0 hour	-
SA264932	CS00000SB-02	QC-Blank	0 hour	-
SA264933	CS00000PB-01	QC-Blank	0 hour	-
SA264934	CS00000PB-04	QC-Blank	0 hour	-
SA264935	CS00000PB-02	QC-Blank	0 hour	-
SA264936	CS00000PB-03	QC-Blank	0 hour	-
SA264937	CS00000MP-04	QC-DriftCorrection	0 hour	-
SA264938	CS00000MP-02	QC-DriftCorrection	0 hour	-
SA264939	CS00000MP-05	QC-DriftCorrection	0 hour	-
SA264940	CS00000MP-03	QC-DriftCorrection	0 hour	-
SA264941	CS00000MP-08	QC-DriftCorrection	0 hour	-
SA264942	CS00000MP-01	QC-DriftCorrection	0 hour	-
SA264943	CS00000MP-09	QC-DriftCorrection	0 hour	-
SA264944	CS00000MP-07	QC-DriftCorrection	0 hour	-
SA264945	CS00000MP-06	QC-DriftCorrection	0 hour	-
SA264946	CS0000OP0-03	QC-Pooled	0 hour	-
SA264947	CS0000OP0-05	QC-Pooled	0 hour	-
SA264948	CS0000OP0-04	QC-Pooled	0 hour	-
SA264949	CS0000OP0-02	QC-Pooled	0 hour	-
SA264950	CS0000OP0-01	QC-Pooled	0 hour	-
SA264951	CS0000OP0-06	QC-Pooled	0 hour	-
SA264952	CS0000OP0-07	QC-Pooled	0 hour	-
SA264953	CS000QCMP-03	QC-Pooled	0 hour	-
SA264954	CS000QCMP-02	QC-Pooled	0 hour	-
SA264955	CS000QCMP-01	QC-Pooled	0 hour	-
SA264956	CS000QCMP-04	QC-Pooled	0 hour	-
SA264957	CS0UMRG01-03	QC-ReCAS	0 hour	-
SA264958	CS0UMRG01-02	QC-ReCAS	0 hour	-
SA264959	CS0UMRG01-04	QC-ReCAS	0 hour	-
SA264960	CS0UMRG01-01	QC-ReCAS	0 hour	-
SA264961	CSMR80016-03	QC-Reference	0 hour	-
SA264962	CSMR80016-02	QC-Reference	0 hour	-
SA264963	CSMR80017-04	QC-Reference	0 hour	-
SA264964	CSMR80016-04	QC-Reference	0 hour	-
SA264965	CSMR80016-01	QC-Reference	0 hour	-
SA264966	CSMR80017-03	QC-Reference	0 hour	-
SA264967	CSMR80017-02	QC-Reference	0 hour	-
SA264968	CSMR80017-01	QC-Reference	0 hour	-
SA264969	90559016606	Training	1 week of training or control time	Female
SA264970	90560016606	Training	1 week of training or control time	Female
SA264971	90567016606	Training	1 week of training or control time	Female
SA264972	90571016606	Training	1 week of training or control time	Female
SA264973	90564016606	Training	1 week of training or control time	Female
SA264974	90426016606	Training	1 week of training or control time	Male
SA264975	90423016606	Training	1 week of training or control time	Male
SA264976	90430016606	Training	1 week of training or control time	Male
SA264977	90422016606	Training	1 week of training or control time	Male
SA264978	90421016606	Training	1 week of training or control time	Male
SA264979	90576016606	Training	2 weeks of training	Female
SA264980	90587016606	Training	2 weeks of training	Female
SA264981	90578016606	Training	2 weeks of training	Female
SA264982	90585016606	Training	2 weeks of training	Female
SA264983	90581016606	Training	2 weeks of training	Female
SA264984	90441016606	Training	2 weeks of training	Male
SA264985	90449016606	Training	2 weeks of training	Male
SA264986	90444016606	Training	2 weeks of training	Male
SA264987	90439016606	Training	2 weeks of training	Male
SA264988	90450016606	Training	2 weeks of training	Male
SA264989	90420016606	Training	4 weeks of training	Female
SA264990	90406016606	Training	4 weeks of training	Female
SA264991	90410016606	Training	4 weeks of training	Female
SA264992	90412016606	Training	4 weeks of training	Female
SA264993	90416016606	Training	4 weeks of training	Female
SA264994	90280016606	Training	4 weeks of training	Male
SA264995	90292016606	Training	4 weeks of training	Male
SA264996	90283016606	Training	4 weeks of training	Male
SA264997	90281016606	Training	4 weeks of training	Male
SA264998	90289016606	Training	4 weeks of training	Male
SA264999	90251016606	Training	8 weeks of training or control time	Female
SA265000	90259016606	Training	8 weeks of training or control time	Female
SA265001	90267016606	Training	8 weeks of training or control time	Female
SA265002	90258016606	Training	8 weeks of training or control time	Female
SA265003	90254016606	Training	8 weeks of training or control time	Female
SA265004	90227016606	Training	8 weeks of training or control time	Male
SA265005	90218016606	Training	8 weeks of training or control time	Male
SA265006	90222016606	Training	8 weeks of training or control time	Male
SA265007	90223016606	Training	8 weeks of training or control time	Male
SA265008	90225016606	Training	8 weeks of training or control time	Male

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