Summary of Study ST002697

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001669. The data can be accessed directly via it's Project DOI: 10.21228/M8ZQ5Q This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST002697
Study TitleEmploying Hindlimb Unloading Model for The Identification of Serum Biomarkers Associated with Cardiovascular and Skeletal Muscle Deconditioning.
Study SummaryMicrogravity and prolonged periods of inactivity cause a variety of diseases, including skeletal muscle mass loss and weakening as well as cardiovascular deconditioning. The primary causes of the inadequate preventative measures for these deconditionings are the lack of biomarkers and unknown underlying mechanisms of cardiovascular and skeletal muscle deconditioning in these conditions. Here, we used a hindlimb unloading (HU) mouse model that replicates astronauts in space and bedridden patients to first evaluate cardiovascular and skeletal muscle performance. Serum samples from these mice were used to identify new biomarkers using metabolomic and proteomic approaches. Three weeks of unloading resulted in alterations in cardiovascular system function in C57/Bl6 mice, as measured by changes in mean arterial pressure and heart weight. Unloading for three weeks also altered skeletal muscle function, resulting in a decrease of grip strength in HU mice, as well as skeletal muscle atrophy, as shown by a drop in muscle mass. A two-week recovery time from the unloading condition partially reversed these alterations, stressing the importance of the recovery process.
Institute
Sharjah Institute for Medical Research
Last NameFacility
First NameCore
AddressM32, SIMR, College of Pharmacy, Health Sciences, University of Sharjah, Sharjah, UAE, Sharjah, 000, United Arab Emirates
Emailtims-tof@sharjah.ac.ae
Phone+971 6 5057656
Submit Date2023-05-02
Raw Data AvailableYes
Raw Data File Type(s)d
Analysis Type DetailLC-MS
Release Date2023-06-02
Release Version1
Core Facility Core Facility
https://dx.doi.org/10.21228/M8ZQ5Q
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Mammal; Subject species: Mus musculus (Factor headings shown in green)

mb_sample_id local_sample_id Group
SA267111CR1-01-8897Control
SA267112CR1-02-8898Control
SA267113C5-02-8896Control
SA267114C4-02-8894Control
SA267115C4-01-8893Control
SA267116CR2-01-8899Control
SA267117CR2-02-8900Control
SA267118CR4-02-8904Control
SA267119CR4-01-8903Control
SA267120CR3-02-8902Control
SA267121CR3-01-8901Control
SA267122C3-02-8892Control
SA267123C5-01-8895Control
SA267124C2-01-8889Control
SA267125C2-02-8890Control
SA267126C3-01-8891Control
SA267127Hu6-01-8908HU
SA267128Hu4-02-8907HU
SA267129Hu6-02-8909HU
SA267130Hu7-02-8911HU
SA267131Hu8-01-8912HU
SA267132Hu8-02-8913HU
SA267133Hu4-01-8906HU
SA267134Hu7-01-8910HU
SA267135HuR2-01-8916HUR
SA267136HuR6-01-8920HUR
SA267137HuR6-02-8921HUR
SA267138HuR3-02-8919HUR
SA267139HuR3-01-8918HUR
SA267140HuR1-02-8915HUR
SA267141HuR2-02-8917HUR
SA267142HuR1-01-8914HUR
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