Summary of Study ST002794

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001742. The data can be accessed directly via it's Project DOI: 10.21228/M8J71N This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

Study ID	ST002794
Study Title	Metabolomics Study on Plasma and Lung Tissue of Rats Exposed to Whole Thorax Irradiation.
Study Summary	Although some progress has been made in the study of radiation injury, there are still no effective prevention and treatment methods for severe acute radiation syndrome or sickness (ARS). Accordingly, a thorough understanding of biological characteristics associated with high-dose radiation is essential for revealing the mechanisms underlying the varied biological processes following high dose radiation and the development of novel potent radioprotective agents. In present study, plasma metabolic characteristics were investigated from patients of hematopoietic stem cell transplantation following high-dose TBI pretreatment utilizing gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS). The most potential panel of four metabolic markers for radiation injury was selected and the metabolic disorders involved were explored. The metabolic disorders implied the dysregulation of gut microflora, shift of energy supply from aerobic respiration to ketogenesis, protein synthesis and metabolism in response to TBI. Although similar metabolic alternation patterns exist between male and female following high-dose irradiation, specific changes are observed in either male or female patients. These findings provide valuable information for further selecting biomarkers, clues of pathogenic mechanisms involved in high-dose radiation exposure.
Institute	Soochow University
Last Name	Wang
First Name	Chang
Address	Suzhou, No. 199, Renai Road, Suzhou Industrial Park
Email	wangchang@suda.edu.cn
Phone	+8651265880067
Submit Date	2023-07-18
Raw Data Available	Yes
Raw Data File Type(s)	raw(Thermo)
Analysis Type Detail	LC-MS
Release Date	2023-08-10
Release Version	1

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Factors:

Subject type: Mammal; Subject species: Rattus norvegicus (Factor headings shown in green)

mb_sample_id	local_sample_id	Treatment
SA299574	20210203-C4-6-5h	Control
SA299575	20210203-C3-6-5h	Control
SA299576	20210203-C5-6-5h	Control
SA299577	20210322-C1-3-72h	Control
SA299578	20210203-C6-1-5h	Control
SA299579	20210203-C8-2-5h	Control
SA299580	20210203-C6-6-5h	Control
SA299581	20210203-C6-4-5h	Control
SA299582	20210322-C1-4-72h	Control
SA299583	20210322-C1-6-72h	Control
SA299584	20210322-C6-1-72h	Control
SA299585	20210322-C6-4-72h	Control
SA299586	20210322-C6-6-72h	Control
SA299587	20210322-C8-2-72h	Control
SA299588	20210322-C5-6-72h	Control
SA299589	20210322-C4-6-72h	Control
SA299590	20210322-C2-1-72h	Control
SA299591	20210322-C3-3-72h	Control
SA299592	20210322-C3-6-72h	Control
SA299593	20210203-C8-6-5h	Control
SA299594	20210308-C3-3-72h	Control
SA299595	20210326-C2-1-48h	Control
SA299596	20210326-C3-3-48h	Control
SA299597	20210326-C3-6-48h	Control
SA299598	20210326-C1-6-48h	Control
SA299599	20210326-C1-4-48h	Control
SA299600	20210331-C1-3-24h	Control
SA299601	20210318-C1-3-5h	Control
SA299602	20210326-C1-3-48h	Control
SA299603	20210326-C4-6-48h	Control
SA299604	20210326-C5-6-48h	Control
SA299605	20210308-C1-4-72h	Control
SA299606	20210308-C1-6-72h	Control
SA299607	20210308-C2-1-72h	Control
SA299608	20210308-C1-3-72h	Control
SA299609	20210326-C8-6-48h	Control
SA299610	20210326-C6-1-48h	Control
SA299611	20210326-C6-4-48h	Control
SA299612	20210326-C8-2-48h	Control
SA299613	20210322-C8-6-72h	Control
SA299614	20210203-C3-3-5h	Control
SA299615	20210324-C1-3-120h	Control
SA299616	20210324-C1-4-120h	Control
SA299617	20210324-C1-6-120h	Control
SA299618	20210308-C8-6-72h	Control
SA299619	20210311-C1-3-120h	Control
SA299620	20210311-C2-1-120h	Control
SA299621	20210311-C1-6-120h	Control
SA299622	20210311-C1-4-120h	Control
SA299623	20210324-C2-1-120h	Control
SA299624	20210324-C3-3-120h	Control
SA299625	20210324-C6-6-120h	Control
SA299626	20210324-C8-2-120h	Control
SA299627	20210324-C8-6-120h	Control
SA299628	20210324-C6-4-120h	Control
SA299629	20210324-C6-1-120h	Control
SA299630	20210324-C3-6-120h	Control
SA299631	20210324-C4-6-120h	Control
SA299632	20210324-C5-6-120h	Control
SA299633	20210311-C3-3-120h	Control
SA299634	20210311-C3-6-120h	Control
SA299635	20210308-C4-6-72h	Control
SA299636	20210308-C5-6-72h	Control
SA299637	20210308-C6-1-72h	Control
SA299638	20210308-C3-6-72h	Control
SA299639	20210203-C1-3-5h	Control
SA299640	20210203-C2-1-5h	Control
SA299641	20210203-C1-6-5h	Control
SA299642	20210203-C1-4-5h	Control
SA299643	20210308-C6-4-72h	Control
SA299644	20210308-C6-6-72h	Control
SA299645	20210311-C6-1-120h	Control
SA299646	20210311-C5-6-120h	Control
SA299647	20210311-C4-6-120h	Control
SA299648	20210311-C6-4-120h	Control
SA299649	20210311-C6-6-120h	Control
SA299650	20210308-C8-2-72h	Control
SA299651	20210311-C8-6-120h	Control
SA299652	20210311-C8-2-120h	Control
SA299653	20210331-C1-6-24h	Control
SA299654	20210326-C6-6-48h	Control
SA299655	20210206-C5-6-48h	Control
SA299656	20210206-C6-1-48h	Control
SA299657	20210206-C6-4-48h	Control
SA299658	20210206-C6-6-48h	Control
SA299659	20210206-C4-6-48h	Control
SA299660	20210206-C3-6-48h	Control
SA299661	20210206-C1-4-48h	Control
SA299662	20210206-C1-6-48h	Control
SA299663	20210206-C2-1-48h	Control
SA299664	20210206-C3-3-48h	Control
SA299665	20210206-C8-2-48h	Control
SA299666	20210206-C8-6-48h	Control
SA299667	20210329-C5-6-24h	Control
SA299668	20210329-C6-1-24h	Control
SA299669	20210329-C6-4-24h	Control
SA299670	20210329-C6-6-24h	Control
SA299671	20210329-C4-6-24h	Control
SA299672	20210329-C3-6-24h	Control
SA299673	20210329-C1-3-24h	Control