Summary of Study ST002861

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001790. The data can be accessed directly via it's Project DOI: 10.21228/M8BD9J This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

Study ID	ST002861
Study Title	Gut Microbiota-associated Metabolites Affected the Susceptibility to Heart Health Abnormality in Young Migrants at High-altitude-Human Serum Metabolomics
Study Summary	Background: Young migrants in plateau are susceptible to heart health abnormality and even high-altitude heart disease (HAHD). Though the gut microbial community was found to be drastically affected when exposed to a hypobaric hypoxia environment, there is limited knowledge about the roles of gut microbiota and gut microbiota-associated serum metabolites (GMSMs) in high-altitude associated heart diseases. Hence, we performed multi-omics integration analysis of 230 graduates from the same university in this study (163 who migrated to Tibet Plateau and 67 matched controls currently living in Chengdu Plain) to explore how the gut microbiota affect the development of high-altitude associated heart health abnormality. Results: Here, we found 206 differential metabolites (82 from serum and 124 from feces) and 369 differential species among the plateau migrants and plain controls. Of these, 27 differential microbial species and 4 differential metabolites (L-Asp, betaine, 3-GUA, and α-KG) that both existed in serum and feces were related to the plateau migrants with undermined heart health (HH-A), which were diagnosed by biomedical detection, electrocardiography (ECG), frequency-domain Cardiogram (FCG) and ultrasonic cardiogram (UCG). Moreover, the abundances of Streptococcus rubneri and Veillonella rogosae were related with the serum levels of L-Asp, betaine, and α-KG in HH-A individuals. And lower these microbiome biomarkers and GMSMs abundances were validated in an independent cohort, both of which together had an excellent discernibility efficacy of heart health abnormality in plateau migrants, with a higher AUC value of 0.7857. Besides, supplement with the two species or each of GMSMs were confirmed to effectively attenuate hypobaric hypoxia-induced higher serum lactic acid, glycolysis, myocardial damage and cardiac hypertrophy. Integrated analysis revealed significant shift in gut microbiome exerted negative regulations in Malate-Aspartate (MA) shuttle, Tricarboxylic acid cycle (TCA) and oxidative phosphorylation in HH-A individuals. Conclusion: Plateau migration altered profoundly the signatures of gut microbiome and metabolome in young migrants. Hypobaric hypoxia-induced lower abundances of Veillonella rogosae, Streptococcus rubneri, and related GMSMs promoted the remodeling of metabolic processes, resulting in higher susceptibility to heart health abnormality in high-altitude. Our findings not only presented elaborate microbial mechanisms, but also provided potential early risk prediction and therapeutic interventions for HAHD.
Institute	Shanghai Center for Systems Biomedicine, Shanghai Jiaotong University
Department	Shanghai Center for Systems Biomedicine
Laboratory	Lu Group
Last Name	Liu
First Name	Jingjing
Address	800 Dongchuan RD. Minhang District, Shanghai, Shanghai, 200240, China
Email	jingjing2018@sjtu.edu.cn
Phone	18818211315
Submit Date	2023-08-30
Raw Data Available	Yes
Raw Data File Type(s)	d
Analysis Type Detail	LC-MS
Release Date	2023-09-27
Release Version	1

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Factors:

Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id	local_sample_id	Treatment
SA308976	A_155	high-altitude group
SA308977	A_154	high-altitude group
SA308978	A_156	high-altitude group
SA308979	A_158	high-altitude group
SA308980	A_159	high-altitude group
SA308981	A_153	high-altitude group
SA308982	A_157	high-altitude group
SA308983	A_152	high-altitude group
SA308984	A_148	high-altitude group
SA308985	A_147	high-altitude group
SA308986	A_149	high-altitude group
SA308987	A_150	high-altitude group
SA308988	A_151	high-altitude group
SA308989	A_160	high-altitude group
SA308990	A_161	high-altitude group
SA308991	A_170	high-altitude group
SA308992	A_169	high-altitude group
SA308993	A_171	high-altitude group
SA308994	A_172	high-altitude group
SA308995	A_173	high-altitude group
SA308996	A_168	high-altitude group
SA308997	A_167	high-altitude group
SA308998	A_163	high-altitude group
SA308999	A_162	high-altitude group
SA309000	A_164	high-altitude group
SA309001	A_165	high-altitude group
SA309002	A_166	high-altitude group
SA309003	A_146	high-altitude group
SA309004	A_144	high-altitude group
SA309005	A_126	high-altitude group
SA309006	A_125	high-altitude group
SA309007	A_127	high-altitude group
SA309008	A_128	high-altitude group
SA309009	A_130	high-altitude group
SA309010	A_129	high-altitude group
SA309011	A_124	high-altitude group
SA309012	A_123	high-altitude group
SA309013	A_119	high-altitude group
SA309014	A_118	high-altitude group
SA309015	A_120	high-altitude group
SA309016	A_121	high-altitude group
SA309017	A_122	high-altitude group
SA309018	A_131	high-altitude group
SA309019	A_132	high-altitude group
SA309020	A_141	high-altitude group
SA309021	A_140	high-altitude group
SA309022	A_142	high-altitude group
SA309023	A_143	high-altitude group
SA309024	A_174	high-altitude group
SA309025	A_139	high-altitude group
SA309026	A_138	high-altitude group
SA309027	A_134	high-altitude group
SA309028	A_133	high-altitude group
SA309029	A_135	high-altitude group
SA309030	A_136	high-altitude group
SA309031	A_137	high-altitude group
SA309032	A_145	high-altitude group
SA309033	A_175	high-altitude group
SA309034	A_212	high-altitude group
SA309035	A_211	high-altitude group
SA309036	A_213	high-altitude group
SA309037	A_214	high-altitude group
SA309038	A_216	high-altitude group
SA309039	A_215	high-altitude group
SA309040	A_210	high-altitude group
SA309041	A_209	high-altitude group
SA309042	A_205	high-altitude group
SA309043	A_204	high-altitude group
SA309044	A_206	high-altitude group
SA309045	A_207	high-altitude group
SA309046	A_208	high-altitude group
SA309047	A_217	high-altitude group
SA309048	A_218	high-altitude group
SA309049	A_227	high-altitude group
SA309050	A_226	high-altitude group
SA309051	A_228	high-altitude group
SA309052	A_229	high-altitude group
SA309053	A_230	high-altitude group
SA309054	A_225	high-altitude group
SA309055	A_224	high-altitude group
SA309056	A_220	high-altitude group
SA309057	A_219	high-altitude group
SA309058	A_221	high-altitude group
SA309059	A_222	high-altitude group
SA309060	A_223	high-altitude group
SA309061	A_203	high-altitude group
SA309062	A_202	high-altitude group
SA309063	A_184	high-altitude group
SA309064	A_183	high-altitude group
SA309065	A_185	high-altitude group
SA309066	A_186	high-altitude group
SA309067	A_187	high-altitude group
SA309068	A_182	high-altitude group
SA309069	A_181	high-altitude group
SA309070	A_177	high-altitude group
SA309071	A_176	high-altitude group
SA309072	A_178	high-altitude group
SA309073	A_179	high-altitude group
SA309074	A_180	high-altitude group
SA309075	A_188	high-altitude group