Summary of Study ST003117
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001936. The data can be accessed directly via it's Project DOI: 10.21228/M8GB12 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST003117 |
| Study Title | Metabolomics of patients with Plasmodium vivax malaria |
| Study Summary | Background: Malaria is the leading parasitic disease worldwide, with P. vivax being a major challenge for its control. Several studies have indicated metabolomics as a promising tool for combating the disease. Objective: The study evaluated plasma metabolomic profiles of patients with recurrent and non-recurrent P. vivax malaria in the Brazilian Amazon. Methods: Metabolites extracted from the plasma of P. vivax-infected patients were subjected to LC-MS analysis. Untargeted metabolomics was applied to investigate the metabolic profile of the plasma in the two groups. Results: Overall, 51 recurrent and 59 non-recurrent patients were included in the study. Longitudinal metabolomic analysis revealed 52 and 37 significant metabolite features from the recurrent and non-recurrent participants, respectively. Recurrence was associated with disturbances in eicosanoid metabolism. Comparison between groups suggest alterations in vitamin B6 (pyridoxine) metabolism, tyrosine metabolism, 3-oxo-10-octadecatrienoate β-oxidation, and alkaloid biosynthesis II. Integrative network analysis revealed enrichment of other metabolic pathways for the recurrent phenotype, including the butanoate metabolism, aspartate and asparagine metabolism, and N-glycan biosynthesis. Conclusion: The metabolites and metabolic pathways predicted in our study suggest potential biomarkers of recurrence and provide insights into targets for antimalarial development against P. vivax. |
| Institute | University of Sao Paulo |
| Last Name | Gardinassi |
| First Name | Luiz Gustavo |
| Address | Av. dos Bandeirantes, 3900, Campus Universitário, Ribeirão Preto, SP, Brazil |
| gardinassi@eerp.usp.br | |
| Phone | 55 16 3315-3395 |
| Submit Date | 2024-03-01 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | mzML |
| Analysis Type Detail | LC-MS |
| Release Date | 2024-04-05 |
| Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Factors:
Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)
| mb_sample_id | local_sample_id | Class | Day | Treatment | Sample source |
|---|---|---|---|---|---|
| SA341187 | ID_22 | non-recurrence | 0 | CQ+PQDHA+PQ422 | Plasma |
| SA341188 | ID_295 | non-recurrence | 0 | CQ+PQDHA+PQ422 | Plasma |
| SA341189 | ID_298 | non-recurrence | 0 | CQ+PQDHA+PQ422 | Plasma |
| SA341190 | ID_82 | non-recurrence | 0 | CQ+PQDHA+PQ422 | Plasma |
| SA341191 | ID_40 | non-recurrence | 0 | CQ+PQDHA+PQ422 | Plasma |
| SA341192 | ID_179 | non-recurrence | 0 | CQ+PQDHA+PQ422 | Plasma |
| SA341193 | ID_300 | non-recurrence | 0 | CQ+PQDHA+PQ422 | Plasma |
| SA341194 | ID_25 | non-recurrence | 0 | CQ+PQDHA+PQ422 | Plasma |
| SA341195 | ID_224 | non-recurrence | 0 | CQ+PQDHA+PQ422 | Plasma |
| SA341196 | ID_61 | non-recurrence | 0 | CQ+PQDHA+PQ422 | Plasma |
| SA341197 | ID_216 | non-recurrence | 0 | CQ+PQDHA+PQ422 | Plasma |
| SA341198 | ID_212 | non-recurrence | 0 | CQ+PQDHA+PQ422 | Plasma |
| SA341199 | ID_250 | non-recurrence | 0 | CQ+PQDHA+PQ422 | Plasma |
| SA341200 | ID_164 | non-recurrence | 0 | CQ+PQDHA+PQ422 | Plasma |
| SA341201 | ID_95 | non-recurrence | 0 | CQ+PQDHA+PQ422 | Plasma |
| SA341202 | ID_278 | non-recurrence | 0 | CQ+PQDHA+PQ422 | Plasma |
| SA341203 | ID_110 | non-recurrence | 0 | CQ+PQDHA+PQ422 | Plasma |
| SA341204 | ID_318 | non-recurrence | 0 | CQ+PQDHA+PQ422 | Plasma |
| SA341205 | ID_5 | non-recurrence | 0 | CQ+PQDHA+PQ422 | Plasma |
| SA341206 | ID_118 | non-recurrence | 0 | CQ+PQDHA+PQ422 | Plasma |
| SA341207 | ID_112 | non-recurrence | 0 | CQ+PQDHA+PQ422 | Plasma |
| SA341208 | ID_266 | non-recurrence | 0 | CQ+PQDHA+PQ422 | Plasma |
| SA341209 | ID_103 | non-recurrence | 0 | CQ+PQDHA+PQ422 | Plasma |
| SA341210 | ID_230 | non-recurrence | 0 | CQ+PQDHA+PQ422 | Plasma |
| SA341211 | ID_145 | non-recurrence | 0 | CQ+PQDHA+PQ422 | Plasma |
| SA341212 | ID_138 | non-recurrence | 0 | CQ+PQDHA+PQ422 | Plasma |
| SA341213 | ID_130 | non-recurrence | 0 | CQ+PQDHA+PQ422 | Plasma |
| SA341214 | ID_151 | non-recurrence | 0 | CQ+PQDHA+PQ422 | Plasma |
| SA341215 | ID_47 | non-recurrence | 0 | CQ+PQ | Plasma |
| SA341216 | ID_173 | non-recurrence | 0 | CQ+PQ | Plasma |
| SA341217 | ID_120 | non-recurrence | 0 | CQ+PQ | Plasma |
| SA341218 | ID_106 | non-recurrence | 0 | CQ+PQ | Plasma |
| SA341219 | ID_99 | non-recurrence | 0 | CQ+PQ | Plasma |
| SA341220 | ID_76 | non-recurrence | 0 | CQ+PQ | Plasma |
| SA341221 | ID_56 | non-recurrence | 0 | CQ+PQ | Plasma |
| SA341222 | ID_313 | non-recurrence | 0 | CQ+PQ | Plasma |
| SA341223 | ID_275 | non-recurrence | 0 | CQ+PQ | Plasma |
| SA341224 | ID_281 | non-recurrence | 0 | CQ+PQ | Plasma |
| SA341225 | ID_248 | non-recurrence | 0 | DHA+PQ42 | Plasma |
| SA341226 | ID_287 | non-recurrence | 0 | DHA+PQ42 | Plasma |
| SA341227 | ID_185 | non-recurrence | 0 | DHA+PQ42 | Plasma |
| SA341228 | ID_234 | non-recurrence | 0 | DHA+PQ42 | Plasma |
| SA341229 | ID_17 | non-recurrence | 0 | DHA+PQ42 | Plasma |
| SA341230 | ID_156 | non-recurrence | 0 | DHA+PQ42 | Plasma |
| SA341231 | ID_192 | non-recurrence | 0 | DHA+PQ42 | Plasma |
| SA341232 | ID_270 | non-recurrence | 0 | DHA+PQ42 | Plasma |
| SA341233 | ID_128 | non-recurrence | 0 | DHA+PQ42 | Plasma |
| SA341234 | ID_289 | non-recurrence | 0 | DHA+PQ42 | Plasma |
| SA341235 | ID_3 | non-recurrence | 0 | DHA+PQ42 | Plasma |
| SA341236 | ID_260 | non-recurrence | 0 | DHA+PQ42 | Plasma |
| SA341237 | ID_161 | non-recurrence | 0 | DHA+PQ | Plasma |
| SA341238 | ID_34 | non-recurrence | 0 | DHA+PQ | Plasma |
| SA341239 | ID_301 | non-recurrence | 0 | DHA+PQ | Plasma |
| SA341240 | ID_206 | non-recurrence | 0 | DHA+PQ | Plasma |
| SA341241 | ID_310 | non-recurrence | 0 | DHA+PQ | Plasma |
| SA341242 | ID_123 | non-recurrence | 0 | DHA+PQ | Plasma |
| SA341243 | ID_243 | non-recurrence | 0 | DHA+PQ | Plasma |
| SA341244 | ID_303 | non-recurrence | 6 | CQ+PQDHA+PQ422 | Plasma |
| SA341245 | ID_188 | non-recurrence | 6 | CQ+PQDHA+PQ422 | Plasma |
| SA341246 | ID_77 | non-recurrence | 6 | CQ+PQDHA+PQ422 | Plasma |
| SA341247 | ID_307 | non-recurrence | 6 | CQ+PQDHA+PQ422 | Plasma |
| SA341248 | ID_105 | non-recurrence | 6 | CQ+PQDHA+PQ422 | Plasma |
| SA341249 | ID_317 | non-recurrence | 6 | CQ+PQDHA+PQ422 | Plasma |
| SA341250 | ID_7 | non-recurrence | 6 | CQ+PQDHA+PQ422 | Plasma |
| SA341251 | ID_12 | non-recurrence | 6 | CQ+PQDHA+PQ422 | Plasma |
| SA341252 | ID_142 | non-recurrence | 6 | CQ+PQDHA+PQ422 | Plasma |
| SA341253 | ID_88 | non-recurrence | 6 | CQ+PQDHA+PQ422 | Plasma |
| SA341254 | ID_154 | non-recurrence | 6 | CQ+PQDHA+PQ422 | Plasma |
| SA341255 | ID_150 | non-recurrence | 6 | CQ+PQDHA+PQ422 | Plasma |
| SA341256 | ID_165 | non-recurrence | 6 | CQ+PQDHA+PQ422 | Plasma |
| SA341257 | ID_199 | non-recurrence | 6 | CQ+PQDHA+PQ422 | Plasma |
| SA341258 | ID_242 | non-recurrence | 6 | CQ+PQDHA+PQ422 | Plasma |
| SA341259 | ID_238 | non-recurrence | 6 | CQ+PQDHA+PQ422 | Plasma |
| SA341260 | ID_283 | non-recurrence | 6 | CQ+PQDHA+PQ422 | Plasma |
| SA341261 | ID_33 | non-recurrence | 6 | CQ+PQDHA+PQ422 | Plasma |
| SA341262 | ID_258 | non-recurrence | 6 | CQ+PQDHA+PQ422 | Plasma |
| SA341263 | ID_43 | non-recurrence | 6 | CQ+PQDHA+PQ422 | Plasma |
| SA341264 | ID_263 | non-recurrence | 6 | CQ+PQDHA+PQ422 | Plasma |
| SA341265 | ID_286 | non-recurrence | 6 | CQ+PQDHA+PQ422 | Plasma |
| SA341266 | ID_54 | non-recurrence | 6 | CQ+PQDHA+PQ422 | Plasma |
| SA341267 | ID_220 | non-recurrence | 6 | CQ+PQDHA+PQ422 | Plasma |
| SA341268 | ID_65 | non-recurrence | 6 | CQ+PQDHA+PQ422 | Plasma |
| SA341269 | ID_210 | non-recurrence | 6 | CQ+PQDHA+PQ422 | Plasma |
| SA341270 | ID_28 | non-recurrence | 6 | CQ+PQDHA+PQ422 | Plasma |
| SA341271 | ID_204 | non-recurrence | 6 | CQ+PQ | Plasma |
| SA341272 | ID_207 | non-recurrence | 6 | CQ+PQ | Plasma |
| SA341273 | ID_314 | non-recurrence | 6 | CQ+PQ | Plasma |
| SA341274 | ID_309 | non-recurrence | 6 | CQ+PQ | Plasma |
| SA341275 | ID_9 | non-recurrence | 6 | CQ+PQ | Plasma |
| SA341276 | ID_38 | non-recurrence | 6 | CQ+PQ | Plasma |
| SA341277 | ID_132 | non-recurrence | 6 | CQ+PQ | Plasma |
| SA341278 | ID_229 | non-recurrence | 6 | CQ+PQ | Plasma |
| SA341279 | ID_127 | non-recurrence | 6 | CQ+PQ | Plasma |
| SA341280 | ID_321 | non-recurrence | 6 | CQ+PQ | Plasma |
| SA341281 | ID_71 | non-recurrence | 6 | DHA+PQ42 | Plasma |
| SA341282 | ID_195 | non-recurrence | 6 | DHA+PQ42 | Plasma |
| SA341283 | ID_268 | non-recurrence | 6 | DHA+PQ42 | Plasma |
| SA341284 | ID_280 | non-recurrence | 6 | DHA+PQ42 | Plasma |
| SA341285 | ID_62 | non-recurrence | 6 | DHA+PQ42 | Plasma |
| SA341286 | ID_172 | non-recurrence | 6 | DHA+PQ42 | Plasma |
