Summary of Study ST003130

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001943. The data can be accessed directly via it's Project DOI: 10.21228/M8K43P This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST003130
Study TitlePulmonary maternal immune activation does not extend through the placenta but leads to fetal metabolic adaptation - Maternal blood
Study SummaryMaternal immune system activation (MIA) during pregnancy can disrupt the fetal environment, causing postnatal susceptibility to disorders. How the placenta and the fetus respond to acute MIA over time is unknown. Here, we characterized the response to acute maternal pulmonary inflammation across time in maternal and fetal organs using multi-omics. Unlike maternal organs which mounted strong innate immune responses, the placenta upregulated tissue-integrity genes, likely to prevent fetal exposure to infections, and downregulated growth-associated genes. Subsequently, the placenta upregulated biosynthesis and endoplasmic reticulum stress genes in order to return to homeostasis. These responses likely protected the fetus, since we observed no immune response in fetal liver. Instead, likely due to nutrient depletion, the fetal liver displayed metabolic adaptations, including increases in lipids containing docosahexaenoic acid, crucial for fetal brain development. Our study shows, for the first time, the integrated temporal response to pulmonary MIA across maternal and fetal organs.
Institute
University of Copenhagen
DepartmentDepartment of Biology
LaboratorySection for Computational and RNA Biology
Last NameSandelin
First NameAlbin
AddressCopenhagen University Ole Maaloes Vej 5, DK2200, Copenhagen N, Denmark
Emailalbin@binf.ku.dk
Phone+45 224 56668
Submit Date2024-03-12
Raw Data AvailableYes
Raw Data File Type(s)mzML
Analysis Type DetailLC-MS
Release Date2024-04-02
Release Version1
Albin Sandelin Albin Sandelin
https://dx.doi.org/10.21228/M8K43P
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Mammal; Subject species: Mus musculus (Factor headings shown in green)

mb_sample_id local_sample_id Sample source exposure timepoint
SA339111Blank02Blank - -
SA339112Blank01Blank - -
SA339113Blank03Blank - -
SA339132P5MBlood ctl 12
SA339133P73MBlood ctl 12
SA339134P97MBlood ctl 12
SA339135P23MBlood ctl 12
SA339136P63MBlood ctl 12
SA339137P13MBlood ctl 12
SA339138P75MBlood ctl 12
SA339139P43MBlood ctl 12
SA339140P93MBlood ctl 2
SA339141P1MBlood ctl 2
SA339142P59MBlood ctl 2
SA339143P51MBlood ctl 2
SA339144P65MBlood ctl 24
SA339145P57MBlood ctl 24
SA339146P81MBlood ctl 24
SA339147P45MBlood ctl 24
SA339148P15MBlood ctl 24
SA339149P70MBlood ctl 24
SA339150P53MBlood ctl 5
SA339151P29MBlood ctl 5
SA339152P39MBlood ctl 5
SA339153P24MBlood lps 12
SA339154P14MBlood lps 12
SA339155P76MBlood lps 12
SA339156P6MBlood lps 12
SA339157P64MBlood lps 12
SA339158P44MBlood lps 12
SA339159P2MBlood lps 2
SA339160P38MBlood lps 2
SA339161P20MBlood lps 2
SA339162P52MBlood lps 2
SA339163P66MBlood lps 24
SA339164P34MBlood lps 24
SA339165P16MBlood lps 24
SA339166P8MBlood lps 24
SA339167P47MBlood lps 24
SA339168P58MBlood lps 24
SA339169P83MBlood lps 24
SA339170P82MBlood lps 24
SA339171P74MBlood lps 24
SA339172P84MBlood lps 24
SA339173P68MBlood lps 5
SA339174P22MBlood lps 5
SA339175P54MBlood lps 5
SA339114QC11MBlood - -
SA339115QC01MBlood - -
SA339116QC12MBlood - -
SA339117QC13MBlood - -
SA339118QC14MBlood - -
SA339119QC10MBlood - -
SA339120QC02MBlood - -
SA339121QC07MBlood - -
SA339122QC08MBlood - -
SA339123QC09MBlood - -
SA339124QC06MBlood - -
SA339125QC05MBlood - -
SA339126QC03MBlood - -
SA339127QC04MBlood - -
SA339128QC16MBlood - -
SA339129QC15MBlood - -
SA339130QC17MBlood - -
SA339131QC18MBlood - -
Showing results 1 to 65 of 65
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