Summary of Study ST003161

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001966. The data can be accessed directly via it's Project DOI: 10.21228/M8KX6R This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST003161
Study TitleDiet-omics in the Study of Urban and Rural Crohn disease Evolution (SOURCE) cohort
Study SummaryCrohn disease (CD) burden has increased with globalization/urbanization, and the rapid rise is attributed to environmental changes rather than genetic drift. The Study Of Urban and Rural CD Evolution (SOURCE, n=380) has considered diet-omics domains simultaneously to detect complex interactions and identify potential beneficial and pathogenic factors linked with rural-urban transition and CD. We characterize exposures, diet, ileal transcriptomics, metabolomics, and microbiome in newly diagnosed CD patients and controls in rural and urban China and Israel. We show that time spent by rural residents in urban environments is linked with changes in gut microbial composition and metabolomics, which mirror those seen in CD. Ileal transcriptomics highlights personal metabolic and immune gene expression modules, that are directly linked to potential protective dietary exposures (coffee, manganese, vitamin D), fecal metabolites, and the microbiome. Bacteria-associated metabolites are primarily linked with host immune modules, whereas diet-linked metabolites are associated with host epithelial metabolic functions.
Institute
Sheba hospital
Last NameBraun
First NameTzipi
AddressSheba hospital, Ramat Gan, Ramat Gan, 52621, Israel
Emailzipik0@gmail.com
Phone97235305000
Submit Date2024-04-03
Raw Data AvailableYes
Raw Data File Type(s)mzML
Analysis Type DetailOther
Release Date2024-04-16
Release Version1
Tzipi Braun Tzipi Braun
https://dx.doi.org/10.21228/M8KX6R
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id Sample source Gender Diagnosis
SA342822025_FC_S042_SOURCE_Female_CDFeces Female CD
SA342823009_FC_S016_SOURCE_Female_CDFeces Female CD
SA342824027_FC_S045_SOURCE_Female_CDFeces Female CD
SA342825005_FC_S011_SOURCE_Female_CDFeces Female CD
SA342826037_FC_S063_SOURCE_Female_CDFeces Female CD
SA342827004_FC_S007_SOURCE_Female_CDFeces Female CD
SA342828001_FC_S002_SOURCE_Female_ControlFeces Female Control
SA342829017_FC_S030_SOURCE_Female_ControlFeces Female Control
SA342830029_FC_S050_SOURCE_Female_ControlFeces Female Control
SA342831035_FC_S061_SOURCE_Female_ControlFeces Female Control
SA342832016_FC_S028_SOURCE_Female_ControlFeces Female Control
SA342833028_FC_S047_SOURCE_Female_ControlFeces Female Control
SA342834019_FC_S032_SOURCE_Female_ControlFeces Female Control
SA342835007_FC_S014_SOURCE_Female_ControlFeces Female Control
SA342836010_FC_S018_SOURCE_Female_ControlFeces Female Control
SA342837012_FC_S022_SOURCE_Female_ControlFeces Female Control
SA342838002_FC_S004_SOURCE_Female_ControlFeces Female Control
SA342839032_FC_S056_SOURCE_Male_CDFeces Male CD
SA342840031_FC_S052_SOURCE_Male_CDFeces Male CD
SA342841034_FC_S060_SOURCE_Male_CDFeces Male CD
SA342842011_FC_S020_SOURCE_Male_CDFeces Male CD
SA342843023_FC_S040_SOURCE_Male_CDFeces Male CD
SA342844020_FC_S033_SOURCE_Male_CDFeces Male CD
SA342845022_FC_S036_SOURCE_Male_CDFeces Male CD
SA342846013_FC_S024_SOURCE_Male_CDFeces Male CD
SA342847014_FC_S025_SOURCE_Male_CDFeces Male CD
SA342848021_FC_S035_SOURCE_Male_CDFeces Male CD
SA342849006_FC_S012_SOURCE_Male_ControlFeces Male Control
SA342850033_FC_S057_SOURCE_Male_ControlFeces Male Control
SA342851036_FC_S062_SOURCE_ControlFeces Male Control
SA342852003_FC_S006_SOURCE_Male_ControlFeces Male Control
SA342853026_FC_S044_SOURCE_Male_ControlFeces Male Control
SA342854018_FC_S031_SOURCE_Male_ControlFeces Male Control
SA342855024_FC_S041_SOURCE_Male_ControlFeces Male Control
SA342856015_FC_S026_SOURCE_Male_ControlFeces Male Control
SA342857008_FC_S015_SOURCE_Male_ControlFeces Male Control
SA342858030_FC_S051_SOURCE_Male_ControlFeces Male Control
Showing results 1 to 37 of 37
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