Summary of study ST001325

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000902. The data can be accessed directly via it's Project DOI: 10.21228/M83D67 This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST001325
Study TitleObesity and Poor Diet as Susceptibility Factors for Secondhand Smoke in Childhood Asthma
Study TypeMS analysis
Study SummaryAim 1: To investigate the effect of SHS exposure on asthma morbidity, systemic inflammation and oxidative stress among inner-city children with asthma. Hypotheses 1.Increasing SHS exposure will be associated with increases in asthma morbidity, systemic inflammation and oxidative stress. Aim 2: To determine if being overweight/obese modifies the effect of SHS exposure on respiratory symptoms, inflammation and oxidative stress responses among inner-city children with asthma.Hypothesis 2. SHS exposure will be associated with a worsened asthma and increases in systemic inflammation and oxidative stress among overweight/obese children compared to normal weight children. Aim 3: To determine if diet quality modifies the effect of SHS exposure on respiratory symptoms, inflammation and oxidative stress responses among inner-city children with asthma. Hypothesis 3. SHS smoke exposure will associated with worsened respiratory symptoms and increases in inflammation and oxidative stress among children with poor quality diet compared those with better quality diet inner-city children with asthma. (Diet will be assessed by dietary inflammatory index, healthy eating index, and additional serum markers proposed in this application).
Institute
University of Michigan
DepartmentBiomedical Research Core Facilities
LaboratoryMetabolomics core
Last NameKachman
First NameMaureen
AddressAnn Arbor, MI
Emailmkachman@med.umich.edu
Phone734-232-0842
Submit Date2020-02-26
Total Subjects185
Study CommentsLow-income minority children in urban areas often inhabit an environment that has excessive pollution and these children are at risk for obesity and poor diet. Secondhand smoke (SHS) is a common exposure in homes of children in Baltimore City and approximately 50-80% of households have a smoker. Secondhand smoke has been associated with worse asthma outcomes. We hypothesize that secondhand smoke exposure will be associated with increases in asthma morbidity and increases in systemic markers of inflammation and oxidative stress and that these responses will be exaggerated among overweight and obese children compared with normal weight and among those with poor diets compared to better diets among children with asthma.
Raw Data AvailableYes
Raw Data File Type(s).d
Chear StudyYes
Analysis Type DetailLC-MS
Release Date2021-08-31
Release Version1
Maureen Kachman Maureen Kachman
https://dx.doi.org/10.21228/M83D67
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

Select appropriate tab below to view additional metadata details:


Combined analysis:

Analysis ID AN002204 AN002205 AN002206 AN002207
Analysis type MS MS MS MS
Chromatography type Reversed phase Reversed phase Reversed phase Reversed phase
Chromatography system Agilent 1290 Infinity II Agilent 1290 Infinity II Agilent 1290 Infinity II Agilent 1290 Infinity II
Column Waters Acquity BEH C18 (100 x 2mm, 1.7um) Waters Acquity BEH C18 (100 x 2mm, 1.7um) Waters Acquity BEH C8 (100 x 2.1mm, 1.7um) Waters Acquity BEH C8 (100 x 2.1mm, 1.7um)
MS Type ESI ESI ESI ESI
MS instrument type QTOF QTOF QTOF QTOF
MS instrument name Agilent 6540 QTOF Agilent 6540 QTOF Agilent 6540 QTOF Agilent 6540 QTOF
Ion Mode POSITIVE NEGATIVE POSITIVE NEGATIVE
Units Peak area normalized Peak area normalized Peak area normalized Peak area normalized

MS:

MS ID:MS002050
Analysis ID:AN002204
Instrument Name:Agilent 6540 QTOF
Instrument Type:QTOF
MS Type:ESI
MS Comments:MS1 acquisition followed by recursive search using Agilent Qualitative analysis software, MPP and in-house software for alignment and reporting. Final data reduction using Binner
Ion Mode:POSITIVE
  
MS ID:MS002051
Analysis ID:AN002205
Instrument Name:Agilent 6540 QTOF
Instrument Type:QTOF
MS Type:ESI
MS Comments:MS1 acquisition followed by recursive search using Agilent Qualitative analysis software, MPP and in-house software for alignment and reporting. Final data reduction using Binner
Ion Mode:NEGATIVE
  
MS ID:MS002052
Analysis ID:AN002206
Instrument Name:Agilent 6540 QTOF
Instrument Type:QTOF
MS Type:ESI
MS Comments:MS1 acquisition followed by targeted search and manual curation using Agilent ProFinder software
Ion Mode:POSITIVE
  
MS ID:MS002053
Analysis ID:AN002207
Instrument Name:Agilent 6540 QTOF
Instrument Type:QTOF
MS Type:ESI
MS Comments:MS1 acquisition followed by targeted search and manual curation using Agilent ProFinder software
Ion Mode:NEGATIVE
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