Summary of Study ST001383

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000947. The data can be accessed directly via it's Project DOI: 10.21228/M88T2D This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST001383
Study TitleInvestigating exposures and health impacts of endocrine disrupting chemicals among inner-city children.
Study TypeObservational study
Study SummaryOur CHEAR project will conduct untargeted metabolomics analyses among children with and without asthma to gain insight into potential mechanisms related to asthma development. Metabolomics analysis will be conducted in a subset of participants from DISCOVER, a panel study enriched with low-income African American children in Baltimore, MD enrolled from 2009 to 2013. We will conduct untargeted metabolomics in serum collected from 15 children with non-atopic asthma and 22 non-atopic children without asthma. For each child, we will conduct analyses in two serum samples collected 3-9 months apart (total = 74 samples). We will use these pilot data to explore differences in metabolomic profiles among non-atopic children with asthma compared to non-asthmatic controls, and leverage repeated sample measures to assess differences in metabolomic profiles among asthmatic children by symptom frequency or severity. Finally, these data will be used to explore differences in metabolomic profiles by exposure status after urinary organophosphate flame retardant biomarkers have been quantified by CHEAR. Together, these analyses will provide pilot data for future work in our Center to assess potential mechanisms related to asthma development and severity as well as effects of organophoshate flame retardant exposures.
Institute
University of Michigan
DepartmentBiomedical Research Core Facilities
LaboratoryMetabolomics core
Last NameKachman
First NameMaureen
AddressAnn Arbor, MI
Emailmkachman@med.umich.edu
Phone734-232-0842
Submit Date2020-03-18
Raw Data AvailableYes
Raw Data File Type(s)d
Chear StudyYes
Analysis Type DetailLC-MS
Release Date2021-08-31
Release Version1
Maureen Kachman Maureen Kachman
https://dx.doi.org/10.21228/M88T2D
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

Select appropriate tab below to view additional metadata details:


Combined analysis:

Analysis ID AN002304 AN002305 AN002306 AN002307
Analysis type MS MS MS MS
Chromatography type Reversed phase Reversed phase Reversed phase Reversed phase
Chromatography system Agilent 1290 Infinity II Agilent 1290 Infinity II Agilent 1290 Infinity II Agilent 1290 Infinity II
Column Waters Acquity BEH HSS T3 (100 x 2.1mm, 1.8um) Waters Acquity BEH HSS T3 (100 x 2.1mm, 1.8um) Waters Acquity BEH HSS T3 (100 x 2.1mm, 1.8um) Waters Acquity BEH HSS T3 (100 x 2.1mm, 1.8um)
MS Type ESI ESI ESI ESI
MS instrument type QTOF QTOF QTOF QTOF
MS instrument name Agilent 6540 QTOF Agilent 6540 QTOF Agilent 6540 QTOF Agilent 6540 QTOF
Ion Mode POSITIVE NEGATIVE POSITIVE NEGATIVE
Units Peak area normalized Peak area normalized Peak area normalized Peak area normalized

MS:

MS ID:MS002147
Analysis ID:AN002304
Instrument Name:Agilent 6540 QTOF
Instrument Type:QTOF
MS Type:ESI
MS Comments:Untargeted recursive search (Agilent Qual/MPP/In-house software)
Ion Mode:POSITIVE
  
MS ID:MS002148
Analysis ID:AN002305
Instrument Name:Agilent 6540 QTOF
Instrument Type:QTOF
MS Type:ESI
MS Comments:Untargeted recursive search (Agilent Qual/MPP/In-house software)
Ion Mode:NEGATIVE
  
MS ID:MS002149
Analysis ID:AN002306
Instrument Name:Agilent 6540 QTOF
Instrument Type:QTOF
MS Type:ESI
MS Comments:Targeted search (Agilent ProFinder)
Ion Mode:POSITIVE
  
MS ID:MS002150
Analysis ID:AN002307
Instrument Name:Agilent 6540 QTOF
Instrument Type:QTOF
MS Type:ESI
MS Comments:Targeted search (Agilent ProFinder)
Ion Mode:NEGATIVE
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