Summary of Study ST001814

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001147. The data can be accessed directly via it's Project DOI: 10.21228/M8FH7R This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST001814
Study TitleSearching for prognostic biomarkers of Parkinson´s Disease development in the Spanish EPIC cohort through a multiplatform metabolomics approach
Study SummaryThe lack of knowledge about the onset and progression of Parkinson’s disease (PD) hampers its early diagnosis and treatment. We used a multiplatform untargeted metabolomics-based approach to uncover the biochemical remodeling induced by PD in a really early and pre-symptomatic stage and unveiling early potential diagnostic biomarkers. Baseline pre-clinical plasma samples (Pre-PD n=39; control group n=39) were obtained from the European Prospective Study on Nutrition and Cancer (EPIC) cohort, which healthy volunteers were followed for around 15 years to ascertain incident PD. Our finding revealed alterations in fatty acids metabolism, mitochondrial dysfunction, oxidative stress, and gut-brain axis dysregulation. This study is of inestimable value since this is the first study conducted with samples collected many years before the disease development.
Institute
Universidad CEU San Pablo
Last NameGonzalez-Riano
First NameCarolina
Addresskm 0, Universidad CEU-San Pablo Urbanización Montepríncipe. M-501, 28925 Alcorcón
Emailcarolina.gonzalezriano@ceu.es
Phone646251045
Submit Date2021-06-01
Raw Data AvailableYes
Raw Data File Type(s)d
Analysis Type DetailGC-MS/LC-MS
Release Date2021-06-17
Release Version1
Carolina Gonzalez-Riano Carolina Gonzalez-Riano
https://dx.doi.org/10.21228/M8FH7R
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

Select appropriate tab below to view additional metadata details:

Combined analysis:

Analysis ID AN002940 AN002941 AN002942 AN002943
Analysis type MS MS MS MS
Chromatography type Reversed phase Reversed phase GC Normal phase
Chromatography system Agilent 1200 Agilent 1200 Agilent 7890A Agilent 7100 CE
Column Phenomenex Kinetex C18 (150 x 2.1mm,2.6um) Phenomenex Kinetex C18 (150 x 2.1mm,2.6um) Agilent DB5-MS (30m x 0.25mm, 0.25um) Agilent Technologies fused silica capillary 96cm x 50μm
MS Type ESI ESI EI ESI
MS instrument type QTOF QTOF Single quadrupole TOF
MS instrument name Agilent 6520 QTOF Agilent 6520 QTOF Agilent 5975C Agilent 6224 TOF
Ion Mode POSITIVE NEGATIVE UNSPECIFIED POSITIVE
Units AREA AREA AREA

MS:

MS ID:MS002730
Analysis ID:AN002940
Instrument Name:Agilent 6520 QTOF
Instrument Type:QTOF
MS Type:ESI
MS Comments:Agilent Technologies MassHunter WorkStation Data Acquisition B.08.00 software; Agilent Technologies MassHunter Profinder B.08.00 SP1 software (Waldbronn, Germany)
Ion Mode:POSITIVE
  
MS ID:MS002731
Analysis ID:AN002941
Instrument Name:Agilent 6520 QTOF
Instrument Type:QTOF
MS Type:ESI
MS Comments:Agilent Technologies MassHunter WorkStation Data Acquisition B.08.00 software; Agilent Technologies MassHunter Profinder B.08.00 SP1 software (Waldbronn, Germany)
Ion Mode:NEGATIVE
  
MS ID:MS002732
Analysis ID:AN002942
Instrument Name:Agilent 5975C
Instrument Type:Single quadrupole
MS Type:EI
MS Comments:Agilent MSD ChemStation software (Agilent Technologies); Agilent MassHunter Qualitative B.08.00; Agilent MassHunter Unknowns Analysis Tool 9.0.
Ion Mode:UNSPECIFIED
  
MS ID:MS002733
Analysis ID:AN002943
Instrument Name:Agilent 6224 TOF
Instrument Type:TOF
MS Type:ESI
MS Comments:Agilent Technologies MassHunter WorkStation Data Acquisition B.08.00 software; Agilent Technologies MassHunter Profinder B.08.00 SP1 software (Waldbronn, Germany)
Ion Mode:POSITIVE
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