Summary of Study ST001828
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001155. The data can be accessed directly via it's Project DOI: 10.21228/M8DH5P This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST001828 |
| Study Title | Nested case–control study of environmental exposure within the ongoing Puerto Rico Testsite for Exploring Contamination Threats (PROTECT) pregnancy cohort. |
| Study Type | Observational |
| Study Summary | Preterm birth is the leading cause of infant mortality worldwide, and also greatly increases the risk of developing serious health complications in childhood and throughout life. Conditions that contribute to preterm birth remain largely unclear, though an influence by environmental exposures is suspected but poorly understood. In our preliminary work, we found that exposure to common chemicals, such as phthalates and bisphenol A (BPA), may contribute to this serious but understudied public health problem. We also observed strong associations between phthalates/BPA and general markers of oxidative stress, and in turn between these general markers of oxidative stress and risk of preterm birth. In this nested case-control study within an ongoing cohort of pregnant women in Puerto Rico (PROTECT), we will explore untargeted lipidomics, as well as levels of eicosanoids specific to arachidonic acid oxidation pathways, in relation to both environmental exposures and preterm birth. |
| Institute | University of Michigan |
| Department | MRC2 |
| Last Name | Kachman |
| First Name | Maureen |
| Address | Ann Arbor, MI, 48105, USA |
| mkachman@med.umich.edu | |
| Phone | 734-232-0842 |
| Submit Date | 2021-06-11 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | d |
| Analysis Type Detail | LC-MS |
| Release Date | 2021-12-15 |
| Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Combined analysis:
| Analysis ID | AN002964 | AN002965 | AN002966 | AN002967 |
|---|---|---|---|---|
| Analysis type | MS | MS | MS | MS |
| Chromatography type | Reversed phase | Reversed phase | Reversed phase | Reversed phase |
| Chromatography system | Agilent 1290 Infinity II | Agilent 1290 Infinity II | Agilent 1290 Infinity II | Agilent 1290 Infinity II |
| Column | Waters Acquity BEH C18 (100 x 2mm,1.7um) | Waters Acquity BEH C18 (100 x 2mm,1.7um) | Waters Acquity BEH C18 (100 x 2mm,1.7um) | Waters Acquity BEH C18 (100 x 2mm,1.7um) |
| MS Type | ESI | ESI | ESI | ESI |
| MS instrument type | QTOF | QTOF | QTOF | QTOF |
| MS instrument name | Agilent 6445 Q-TOF | Agilent 6445 Q-TOF | Agilent 6445 Q-TOF | Agilent 6445 Q-TOF |
| Ion Mode | POSITIVE | POSITIVE | NEGATIVE | NEGATIVE |
| Units | Peak area | Peak area | Peak area | Peak area |
MS:
| MS ID: | MS002754 |
| Analysis ID: | AN002964 |
| Instrument Name: | Agilent 6445 Q-TOF |
| Instrument Type: | QTOF |
| MS Type: | ESI |
| MS Comments: | Positive mode untargeted analysis |
| Ion Mode: | POSITIVE |
| MS ID: | MS002755 |
| Analysis ID: | AN002965 |
| Instrument Name: | Agilent 6445 Q-TOF |
| Instrument Type: | QTOF |
| MS Type: | ESI |
| MS Comments: | Positive mode identified compounds |
| Ion Mode: | POSITIVE |
| MS ID: | MS002756 |
| Analysis ID: | AN002966 |
| Instrument Name: | Agilent 6445 Q-TOF |
| Instrument Type: | QTOF |
| MS Type: | ESI |
| MS Comments: | Negative mode untargeted analysis |
| Ion Mode: | NEGATIVE |
| MS ID: | MS002757 |
| Analysis ID: | AN002967 |
| Instrument Name: | Agilent 6445 Q-TOF |
| Instrument Type: | QTOF |
| MS Type: | ESI |
| MS Comments: | Negative mode identified compounds |
| Ion Mode: | NEGATIVE |
