Summary of Study ST000407
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000319. The data can be accessed directly via it's Project DOI: 10.21228/M8H029 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Study ID | ST000407 |
| Study Title | Arsenic and the fecal metabolome |
| Study Summary | The goal of this study was to identify metabolic differences between 6 week old and 1 year old infants that have been potentially exposed to arsenic in order to determine its effect on the microbiome and the immune system. |
| Institute | RTI International |
| Laboratory | Systems and Translational Sciences |
| Last Name | Sumner |
| First Name | Susan |
| Address | 3040 E. Cornwallis Road |
| jpb@rti.org | |
| Phone | 919-541-6700 |
| Submit Date | 2016-06-02 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | 1r |
| Analysis Type Detail | NMR |
| Release Date | 2018-08-27 |
| Release Version | 1 |
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Project:
| Project ID: | PR000319 |
| Project DOI: | doi: 10.21228/M8H029 |
| Project Title: | Metabolomics Changes in the feces of infants exposed to arsenic |
| Project Summary: | Exposure to arsenic (As) during the vulnerable window of fetal development and early childhood has shown significant clinical effects. In highly exposed populations, altered immunity is one of the most affected pathways and can lead to an elevated risk of infection and a pre-disposition to allergy/atopy. Since well water in the New Hampshire region has been determined to be a potential source of As exposure, this study includes mother-infant dyads living in the area, who obtain household water from private wells. This study seeks to determine if in utero and early life As exposure is related to increase occurrence of childhood: infections, allergy and atopy, and diminished vaccine response. It has been observed that the microbiome is an important mediator of immune impairment due to As exposure. Therefore, we will further investigate the relation between in utero and early life As exposure on the development of the infant intestinal microbiome in the first year of life. For this study fecal samples, from infants at risk of As exposure, were collected at 6 weeks and 12 months of age. Metabolomics data will allow for a more complete picture of the relationships between the microbiome, As exposure and immune function. |
| Institute: | Dartmouth College |
| Department: | Department of Epidemiology |
| Last Name: | Margaret |
| First Name: | Karagas |
| Address: | One Medical Center Road, 7927 HB, Rubin Building, Lebanon, NH 03756 |
| Email: | Margaret.Karagas@Dartmouth.edu |
| Phone: | 603-653-9010 |
