Summary of Study ST000559
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000410. The data can be accessed directly via it's Project DOI: 10.21228/M82889 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Study ID | ST000559 |
| Study Title | Urine metabolomic profiling of diabetic nephropathy in the steptozotocin induced type-1 diabetes mouse model. |
| Study Summary | This metabolomics study evaluated urine from wild-type and meprin β knockout mice after induction of diabetes with streptozotocin or treatment with sodium citrate control to understand how these factors influence the metabotype. |
| Institute | RTI International |
| Laboratory | NIH Eastern Regional Comphrehensive Metabolomics Resource Core at UNC Chapel Hill (ERCMRC) |
| Last Name | Sumner |
| First Name | Susan |
| Address | 3040 E. Cornwallis Road, Research Triangle Park, NC 27709 |
| susan_sumner@unc.edu | |
| Phone | 704-250-5000 |
| Submit Date | 2017-02-17 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | raw(Waters) |
| Analysis Type Detail | LC-MS |
| Release Date | 2018-04-10 |
| Release Version | 1 |
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Project:
| Project ID: | PR000410 |
| Project DOI: | doi: 10.21228/M82889 |
| Project Title: | Urine metabolomic profiling of diabetic nephropathy in the steptozotocin induced type-1 diabetes mouse model. |
| Project Summary: | Diabetic nephropathy (DN) is the leading cause of end stage renal disease, and is associated with high morbidity and mortality rates. The pathophysiology of DN includes both glomerular and tubulointerstitial damage. Meprins are metalloproteinases which are most abundantly expressed in the brush border membranes of proximal kidney tubules. Meprins are also expressed in leukocytes (monocytes and macrophages) and podocytes. Meprins have been implicated in the pathology of acute and chronic kidney injury. Single nucleotide polymorphisms (SNPs) in the meprin β gene were associated in human DN in the Pima Indians, suggesting a role for meprins in the pathophysiology of DN. The current study was done to determine the mechanisms by which meprins modulate the progression of DN in mice. |
| Institute: | North Carolina A&T State University |
| Department: | Department of Biology |
| Last Name: | Ongeri |
| First Name: | Elimelda Moige |
| Address: | 1601 E Market Street, Greensboro, NC 27411 |
| Email: | eongeri@ncat.edu |
| Phone: | 336-285-2182 |
| Funding Source: | NIH/NIGMS Grant # SC3102049 To Elimelda Moige Ongeri; NIH Center Grant # U24DK097193 to Susan Sumner; NIH/NCATS award # UL1TR001111 to John Buse, UNC-CH, PI, Sumner- Director, Metabolomics core; and NIH/NIGMS Grant # K01GM109320 to Jessica Gooding. |
