Summary of Study ST001807
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001141. The data can be accessed directly via it's Project DOI: 10.21228/M8711S This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST001807 |
| Study Title | Untargeted metabolomics of Daphnia magna exposed to a lithium cobalt oxide nanomaterial |
| Study Type | Untargeted MS |
| Study Summary | The goal of this project was to determine lithium cobalt oxide (LCO)’s effects on pathways in the model organism Daphnia magna through untargeted metabolomics. |
| Institute | University of Wisconsin - Milwaukee |
| Department | School of Freshwater Sciences |
| Laboratory | Rebecca Klaper |
| Last Name | Klaper |
| First Name | Rebecca |
| Address | 600 E Greenfield Ave, Milwaukee, WI 53204 |
| rklaper@uwm.edu | |
| Phone | 4143821713 |
| Submit Date | 2021-05-18 |
| Num Groups | 4 |
| Total Subjects | 36 |
| Study Comments | Pooled samples of 20 Daphnia magna per replicate. |
| Raw Data Available | Yes |
| Raw Data File Type(s) | mzXML |
| Analysis Type Detail | MS(Dir. Inf.) |
| Release Date | 2022-05-19 |
| Release Version | 1 |
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Project:
| Project ID: | PR001141 |
| Project DOI: | doi: 10.21228/M8711S |
| Project Title: | Energy starvation in Daphnia magna from exposure to a lithium cobalt oxide nanomaterial |
| Project Type: | Untargeted MS |
| Project Summary: | Our previous research demonstrated that energy metabolism is significantly impacted in sediment-dwelling invertebrate Chironomus riparius upon exposure to metal oxide nanomaterial lithium cobalt oxide (LCO), used as a cathode material in lithium-ion batteries, an impact that is not replicated by ion controls. To further explore metabolic impacts, we determined LCO’s effects on model organism Daphnia magna using untargeted metabolomics. Our results show a sublethal 1 mg/L 48 h LCO exposure causes significant impacts on D. magna metabolites, while ion control exposure equivalent to released Li and Co had no impact, showing the nano-specificity of LCO impacts. Specifically, metabolomic analysis indicated alteration of metabolites related to amino acid metabolism and starch, sucrose, and galactose metabolism as a result of LCO exposure. |
| Institute: | University of Wisconsin - Milwaukee |
| Department: | School of Freshwater Sciences |
| Laboratory: | Rebecca Klaper |
| Last Name: | Niemuth |
| First Name: | Nicholas |
| Address: | 600 E Greenfield Ave, Milwaukee, WI, 53204, USA |
| Email: | niemuthn@uwm.edu |
| Phone: | 4143821763 |
| Funding Source: | National Science Foundation CHE-2001611 |
| Contributors: | Nicholas J Niemuth, Becky J Curtis, Elizabeth D Laudadio, Jelena Sostare, Evan A Bennett, Nicklaus J Neureuther, Mark R Viant, Robert J Hamers, Rebecca D Klaper |
