Summary of Study ST001960
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001247. The data can be accessed directly via it's Project DOI: 10.21228/M8HT3Z This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Study ID | ST001960 |
| Study Title | Lipidomics of brown adipocytes treated with d9-choline |
| Study Type | targeted LC-QTOF/MS lipidomic profiling |
| Study Summary | Brown adipose tissue (BAT) was initially characterised as a thermogenic organ, and recent studies have suggested it plays a crucial role in maintaining systemic metabolic health. In this project, we demonstrated that alteration of BAT function contributes to development of heart failure through disorientation in choline metabolism. To analyze the detail effect of choline accumulation on brown adipocytes, we conducted the LC-QTOF/MS analysis using cultured brown adipocytes treated with d9-choline. In brown adipocytes treated with d9-choline, we found increase of phosphatidylcholine and lysophosphatidylcholine, suggesting that choline was metabolized in healthy brown adipocytes. |
| Institute | Juntendo University |
| Department | Department of Cardiovascular Biology and Medicine |
| Last Name | Yoshida |
| First Name | Yohko |
| Address | 2-1-1, Hongo, Bunkyo-ku, Tokyo, Tokyo, 1138421, Japan |
| yohko105@yahoo.co.jp | |
| Phone | +81-3-3813-3111 |
| Submit Date | 2021-10-14 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | d |
| Analysis Type Detail | LC-MS |
| Release Date | 2022-11-01 |
| Release Version | 1 |
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Project:
| Project ID: | PR001247 |
| Project DOI: | doi: 10.21228/M8HT3Z |
| Project Title: | Lipidomics of brown adipocytes treated with d9-choline |
| Project Type: | targeted LC-QTOF/MS lipidomic profiling |
| Project Summary: | Brown adipose tissue (BAT) was initially characterised as a thermogenic organ, and recent studies have suggested it plays a crucial role in maintaining systemic metabolic health. In this project, we demonstrated that alteration of BAT function contributes to development of heart failure through disorientation in choline metabolism. To analyze the detail effect of choline accumulation on brown adipocytes, we conducted the LC-QTOF/MS analysis using cultured brown adipocytes treated with d9-choline. In brown adipocytes treated with d9-choline, we found increase of phosphatidylcholine and lysophosphatidylcholine, suggesting that choline was metabolized in healthy brown adipocytes. |
| Institute: | Juntendo University |
| Department: | Department of Cardiovascular Biology and Medicine |
| Last Name: | Yoshida |
| First Name: | Yohko |
| Address: | 2-1-1, Hongo, Bunkyo-ku, Tokyo, Tokyo, 1138421, Japan |
| Email: | yohko105@yahoo.co.jp |
| Phone: | +81-3-3813-3111 |
