Summary of Study ST002355
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001512. The data can be accessed directly via it's Project DOI: 10.21228/M8812G This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST002355 |
| Study Title | Stool short chain fatty acid (SCFA) levels in peanut allergy |
| Study Summary | Prior evidence supports differential levels of short chain fatty acids in the stool of human beings with allergy and murine models of allergy. Here we performed a targeted study of selected short chain fatty acid levels in stool samples collected from children with allergy risk factors. Sample processing included homogenization of stool samples, inclusion of internal standards, and derivitization for liquid chromatography tandem mass spectrometry. |
| Institute | Icahn School of Medicine at Mount Sinai |
| Last Name | Bunyavanich |
| First Name | Supinda |
| Address | 1 Gustave L. Levy Pl, New York, NY 10029 |
| supinda.bunyavanich@mssm.edu | |
| Phone | Stool metabolite levels in individuals with peanut allergy were measured. |
| Submit Date | 2022-11-08 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | mzXML |
| Analysis Type Detail | LC-MS |
| Release Date | 2023-12-08 |
| Release Version | 1 |
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Project:
| Project ID: | PR001512 |
| Project DOI: | doi: 10.21228/M8812G |
| Project Title: | Stool metabolites in peanut allergy |
| Project Summary: | Rising rates of peanut allergy motivate investigations of its development to inform prevention and therapy. Microbiota and the metabolites they produce shape food allergy risk. We performed a longitudinal, multi-center, integrative study of the gut microbiome and metabolome of 122 infants with allergy risk factors but no peanut allergy who were followed through mid childhood. 28.7% of infants developed peanut allergy by mid-childhood. Lower infant gut microbiome diversity was associated with peanut allergy development (P=0.014). Peanut allergy-bound children had different abundance trajectories of Clostridium sensu stricto 1 sp. (FDR=0.015) and Bifidobacterium sp. (FDR=0.033), with butyrate (FDR=0.045) and isovalerate (FDR=0.036) decreasing over time. Metabolites associated with peanut allergy development clustered within the histidine metabolism pathway. Positive correlations between microbiota, butyrate, and isovalerate and negative correlations with histamine marked the peanut allergy free network. The temporal dynamics of the gut microbiome and metabolome in early childhood are distinct for children who develop peanut allergy. |
| Institute: | Icahn School of Medicine at Mount Sinai |
| Last Name: | Bunyavanich |
| First Name: | Supinda |
| Address: | 1 Gustave L. Levy Pl, New York, NY 10029 |
| Email: | supinda.bunyavanich@mssm.edu |
| Phone: | 212-241-5548 |
