Summary of Study ST002535
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001631. The data can be accessed directly via it's Project DOI: 10.21228/M8W43G This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST002535 |
| Study Title | Relationships between the gut microbiome and cognitive impairment in residents of long-term aged care. |
| Study Summary | Ageing-associated cognitive decline affects more than half of those in long-term residential aged care. Emerging evidence suggests that gut microbiome-host interactions influence the effects of modifiable risk factors. We investigated the relationship between gut microbiome characteristics and severity of cognitive impairment (CI) in 159 residents of long-term aged care. Severe CI was associated with a significantly increased abundance of proinflammatory bacterial species, including Methanobrevibacter smithii and Alistipes finegoldii, and decreased relative abundance of beneficial bacterial clades. Severe CI was associated with increased microbial capacity for methanogenesis, and reduced capacity for synthesis of short-chain fatty acids, neurotransmitters glutamate and gamma-aminobutyric acid, and amino acids required for neuro-protective lysosomal activity. These relationships were independent of age, sex, antibiotic exposure, and diet. Our findings implicate multiple gut microbiome-brain pathways in ageing-associated cognitive decline, including inflammation, neurotransmission, and autophagy, and highlight the potential to predict and prevent cognitive decline through microbiome-targeted strategies. |
| Institute | South Australian Health and Medical Research Institute |
| Last Name | Shoubridge |
| First Name | Andrew |
| Address | North Terrace, Adelaide, South Australia, 5000, Australia |
| andrew.shoubridge@sahmri.com | |
| Phone | +61405041977 |
| Submit Date | 2023-03-26 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | mzML |
| Analysis Type Detail | LC-MS |
| Release Date | 2023-04-04 |
| Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Project:
| Project ID: | PR001631 |
| Project DOI: | doi: 10.21228/M8W43G |
| Project Title: | Metabolomic Profiling of Human Faecal Samples |
| Project Summary: | Targeted analysis of SCFAs and polar metabolites in samples from human faeces. |
| Institute: | South Australian Health and Medical Research Institute |
| Department: | Lifelong Health |
| Laboratory: | Microbiome and Host Health Programme |
| Last Name: | Shoubridge |
| First Name: | Andrew |
| Address: | North Terrace, Adelaide, South Australia, 5000, Australia |
| Email: | andrew.shoubridge@sahmri.com |
| Phone: | +61405041977 |
