Summary of Study ST003159
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001964. The data can be accessed directly via it's Project DOI: 10.21228/M8VD96 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST003159 |
| Study Title | Untargeted serum metabolomics in the Parkinson's Environment and Genes (PEG) Study |
| Study Summary | This project aims to evaluate the serum metabolome of Parkinson’s disease (PD) patients relative to unaffected controls in the Parkinson’s Environment and Genes (PEG) Study. Background: Untargeted high-resolution metabolomic profiling provides simultaneous measurement of thousands of metabolites. Metabolic networks based on these data can help uncover disease-related perturbations across interconnected pathways. Objective: Identify metabolic disturbances associated with PD in the PEG population-based study using untargeted metabolomics. Methods: We provide serum-based untargeted metabolomics data derived from liquid chromatography with high-resolution mass spectrometry (LC-HRMS). LC-HRMS detected 4,762 metabolites for analysis (HILIC: 2716 metabolites; C18: 2046 metabolites). |
| Institute | University of California, Los Angeles |
| Department | Neurology |
| Last Name | Paul |
| First Name | Kimberly |
| Address | 710 Westwood Plaza, Los Angeles, CA, 90095, USA |
| kimberlp@ucla.edu | |
| Phone | 310.206.7458 |
| Submit Date | 2023-12-15 |
| Total Subjects | 919 |
| Analysis Type Detail | LC-MS |
| Release Date | 2024-04-23 |
| Release Version | 1 |
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Sample Preparation:
| Sampleprep ID: | SP003284 |
| Sampleprep Summary: | Blood samples were drawn from participants during field visits. Samples were centrifuged, kept on dry ice, and then stored in a −80 °C freezer at UCLA. Serum samples were shipped frozen to Emory University on dry ice for metabolomics analyses, where they were stored at −80 °C until LC-MS analysis. High-Resolution Metabolomics (HRM) was conducted according to established methods at Emory University (Clincal Biomarkers Laboratory). See the attached SOP protocol. Methods related to the PEG study population and data processing are found in Study_Methods.pdf |
| Sampleprep Protocol Filename: | EmoryUniversity_HRM_SP_082016_01.pdf |
