Summary of Study ST000168
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000146. The data can be accessed directly via it's Project DOI: 10.21228/M83G6X This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Study ID | ST000168 |
| Study Title | Effect of Insulin Sensitizer Therapy on Amino Acids and Their Metabolites |
| Study Type | drug + time course |
| Study Summary | We previously reported the overall study design for the parent study [29]. The current report primarily examines the effect of three months of insulin sensitizer therapy on plasma concentrations of BCAA, AAA, and AA metabolites in overweight/obese adults with fasting hyperglycemia, defined as either impaired fasting glucose or untreated diabetes [29]. Briefly, 25 drug naïve, Northern European American participants with fasting blood glucose concentrations of 108180 mg/dL were randomized to receive either 45 mg of pioglitazone per day plus 1 g of metformin twice per day (n = 12) or placebo (n = 13) for 12 weeks. We chose metformin based on its proven effect on hepatic insulin sensitivity and pioglitazone based on its effect on peripheral insulin sensitivity. Current use of hypoglycemic medications excluded participants from the present study. |
| Institute | Mayo Clinic |
| Department | Endocrinology |
| Laboratory | Sree Nair |
| Last Name | Nair |
| First Name | Sreekumaran |
| Dasari.Surendra@mayo.edu | |
| Submit Date | 2015-05-21 |
| Num Groups | 2 |
| Total Subjects | 27 |
| Raw Data Available | No |
| Analysis Type Detail | LC-MS |
| Release Date | 2015-06-28 |
| Release Version | 1 |
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Subject:
| Subject ID: | SU000187 |
| Subject Type: | Human |
| Subject Species: | Homo sapiens |
| Taxonomy ID: | 9606 |
| Species Group: | Mammals |
