Summary of Study ST001048

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000702. The data can be accessed directly via it's Project DOI: 10.21228/M8XT3P This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

Study ID	ST001048
Study Title	Pediatric Inner-City Environmental Exposures at School and Home and Asthma Study
Study Type	CHEAR Study
Study Summary	SICAS 1 and SICAS 2 have extraordinary opportunity to evaluate the role of diet, environmental exposures and asthma in the context of school and home specific exposures and capitalize on all the data we are already collecting. Asthma affects 25 million Americans, particularly urban minority children. Children spend nearly all day in school, yet little is known about the role of a child’s exposure to widely disseminated industrial chemicals on asthma morbidity. Early animal models and population studies have begun to identify an association between phenolic chemical exposure and asthma development through proposed increased regulation of an individual’s allergic immune response. This study, nested within a school-based environmental intervention trial, (School Inner-City Asthma Intervention Study, SICAS2) , will enable urinary biomarker analyses during a school-based academic year-long environmental intervention trial to analyze the source and impact of exposures on urinary environmental exposure biomarker levels as well as the relationship between these biomarkers levels and asthma morbidity. We are poised to leverage the clinical and exposure data being collected in the clinical trial and generate cross-sectional urinary phenol biomarker data (at baseline) within the resources of CHEAR. If successful, our study will assess the impact of exposures on these biomarker levels and the impact that these exposures have on asthma morbidity, controlling comprehensively for other personal, home, and school environmental factors associated with asthma outcomes. We hypothesize that exposure to environmental exposures (e.g. phenols, phthalates, environmental tobacco smoke) in urban school children and higher urinary biomarkers will preliminarily be associated with higher asthma morbidity. Specific aims are: Aim 1. To determine the source of exposure to environmental exposures (e.g. phenols, phthalates, environmental tobacco smoke) in inner-city school children as assessed by questionnaire, product use assessment and comprehensive school and home environmental assessment of children with physician-diagnosed asthma. Aim 2. To determine whether urinary phenol/phathalate/cotinine biomarkers are associated with asthma control (e.g. asthma symptoms, such as asthma-related symptom days (primary outcome), and other phenotypes of asthma/allergic symptoms and inflammation such as allergic sensitization, health care utilization and pulmonary lung function
Institute	Icahn School of Medicine at Mount Sinai
Department	Department of Environmental Medicine and Public Health
Laboratory	Mount Sinai CHEAR Untargeted Laboratory Hub
Last Name	Walker
First Name	Douglas
Address	Atran Building RM AB3-39, 1428 Madison Ave
Email	douglas.walker@mssm.edu
Phone	212-241-4392
Submit Date	2018-08-22
Raw Data Available	Yes
Raw Data File Type(s)	d
Chear Study	Yes
Analysis Type Detail	LC-MS
Release Date	2021-08-31
Release Version	1

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Treatment:

Treatment ID:	TR001104
Treatment Summary:	This study will use a cross-sectional design and nested case control comparison of inner-city children with poorly controlled asthma versus those with well-controlled asthma. Participants will be eligible for the study if they attend one of the inner-city schools sampled in SICAS-2 and have a physician diagnosis of asthma. SICAS2 is a factorial randomized double-blinded, placebo-controlled classroom air cleaner intervention [High Efficiency Particulate Air (HEPA) filter/purifying units]/ integrated pest management (IPM) intervention. Baseline Clinical measures: Prior to randomization (a) at a clinic visit we will assess clinical characteristics (asthma symptoms, health care utilization, home characteristics); pulmonary function, FeNO, and allergen sensitivities, and (b) we will assess and sample the school/classroom environment and product use. Parental/child report of personal care product use and dietary history will be ascertained from each study participant. Clinical Follow-up: Enrolled students with asthma, randomized to treatment group by school (IPM) and classroom (HEPA) will be followed during the academic school year. Follow-up phone health outcomes surveys (e.g., symptoms, health care use; time-activity) will be conducted every 2 months after baseline, yielding evenly-spaced follow-up measures during the school year and 1 after school ends. Home environmental measures will be collected twice by dust sampling. Follow-up school/classroom visits will be conducted twice in opposite seasons to assess/collect week-long environmental classroom allergen/mold/NO2/pollution/endotoxin levels in the dust and air. Classroom/School/Home Exposure Data: The CHEAR resources will support critical analysis of urinary biomarkers at pre-intervention (baseline) during the academic school year prior to randomization and intervention. Urine specimens have been collected from 103 children with asthma at baseline over the first 2 years of the intervention study. These specimens can be linked to classroom/school allergen, mold and air sampling and school environmental questionnaires as well as enrolled students and longitudinal health outcome measures including pulmonary function testing and FeNO measurements.

Treatment ID:

TR001104

Treatment Summary:

This study will use a cross-sectional design and nested case control comparison of inner-city children with poorly controlled asthma versus those with well-controlled asthma. Participants will be eligible for the study if they attend one of the inner-city schools sampled in SICAS-2 and have a physician diagnosis of asthma. SICAS2 is a factorial randomized double-blinded, placebo-controlled classroom air cleaner intervention [High Efficiency Particulate Air (HEPA) filter/purifying units]/ integrated pest management (IPM) intervention. Baseline Clinical measures: Prior to randomization (a) at a clinic visit we will assess clinical characteristics (asthma symptoms, health care utilization, home characteristics); pulmonary function, FeNO, and allergen sensitivities, and (b) we will assess and sample the school/classroom environment and product use. Parental/child report of personal care product use and dietary history will be ascertained from each study participant. Clinical Follow-up: Enrolled students with asthma, randomized to treatment group by school (IPM) and classroom (HEPA) will be followed during the academic school year. Follow-up phone health outcomes surveys (e.g., symptoms, health care use; time-activity) will be conducted every 2 months after baseline, yielding evenly-spaced follow-up measures during the school year and 1 after school ends. Home environmental measures will be collected twice by dust sampling. Follow-up school/classroom visits will be conducted twice in opposite seasons to assess/collect week-long environmental classroom allergen/mold/NO2/pollution/endotoxin levels in the dust and air. Classroom/School/Home Exposure Data: The CHEAR resources will support critical analysis of urinary biomarkers at pre-intervention (baseline) during the academic school year prior to randomization and intervention. Urine specimens have been collected from 103 children with asthma at baseline over the first 2 years of the intervention study. These specimens can be linked to classroom/school allergen, mold and air sampling and school environmental questionnaires as well as enrolled students and longitudinal health outcome measures including pulmonary function testing and FeNO measurements.