Summary of Study ST002254

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001442. The data can be accessed directly via it's Project DOI: 10.21228/M8B71S This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

Study ID	ST002254
Study Title	Maternal obesity alters offspring liver and skeletal muscle metabolism in early post-puberty despite maintaining a normal post-weaning dietary lifestyle
Study Summary	Maternal obesity (MO) during pregnancy is linked to increased and premature risk of age-related metabolic diseases in the offspring. However, the underlying molecular mechanisms still remain not fully understood. Using a well-established baboon model of MO, we analyzed tissue biopsies and plasma samples obtained from post-pubertal offspring (3-6.5y at sample collection) of MO mothers (n=19) and from control animals born to mothers fed a standard diet (CON, n=13). All offspring ate normal chow diet after weaning. With an untargeted gas chromatography-mass spectrometry metabolomics profiling, we quantified a total of 351 liver, 316 skeletal muscle and 423 plasma metabolites. We found 58 metabolites significantly altered in liver and 46 in skeletal muscle of MO offspring, including 8 metabolites shared between both tissues. Male and female-specific metabolites in opposite direction of change were found in liver and skeletal muscle of MO offspring. Several tissue-specific and 4 shared metabolic pathways were identified from these dysregulated metabolites. Interestingly, none of the tissue-specific metabolic alterations reflected in plasma. Our results identify tissue metabolites and pathways in post-pubertal MO offspring in a sex-specific manner.
Institute	Wake Forest School of Medicine
Last Name	Ampong
First Name	Isaac
Address	Center for Precision Medicine, Department of Internal Medicine, Section on Molecular Medicine, Wake Forest University, Winston-Salem, North Carolina, United States
Email	iampong@wakehealth.edu
Phone	3367162091
Submit Date	2022-08-02
Raw Data Available	Yes
Raw Data File Type(s)	mzML
Analysis Type Detail	GC-MS
Release Date	2022-08-31
Release Version	1

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Treatment:

Treatment ID:	TR002352
Treatment Summary:	We analyzed liver and muscle biopsies and plasma samples obtained from the post-pubertal offspring (3-6.5 years old at sample collection) of MO mothers (n=19, 10 females and 9 males) and from control animals born to mothers fed a standard diet (n=13, 6 females and 7 males). All offspring animals ate normal chow diet after weaning so differences between groups are due to the impact of the maternal intrauterine environment.

Treatment ID:

TR002352

Treatment Summary:

We analyzed liver and muscle biopsies and plasma samples obtained from the post-pubertal offspring (3-6.5 years old at sample collection) of MO mothers (n=19, 10 females and 9 males) and from control animals born to mothers fed a standard diet (n=13, 6 females and 7 males). All offspring animals ate normal chow diet after weaning so differences between groups are due to the impact of the maternal intrauterine environment.