Summary of study ST001114

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000745. The data can be accessed directly via it's Project DOI: 10.21228/M8CQ42 This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST001114
Study TitleMetabolomics profile of umbilical cord blood is associated with maternal pre-pregnant obesity in a perspective multi-ethnic cohort displaying health disparities
Study SummaryMaternal obesity has become a growing global health concern that impacts fetal health and subsequently predisposes the offspring to medical conditions later in life. However, the molecular link between abnormal fetal metabolomic profiles and maternal obesity has not yet been fully elucidated. In this study, we report new discoveries from the newborn cord blood metabolomes associated with a case-control maternal obesity cohort, collected from multi-ethnic populations in Hawaii, including rarely reported Native Hawaiian and other Pacific Islanders (NHPI). This cohort displays significant maternal obesity disparities by subjects’ residential area average income and health insurance. An elastic net penalized logistic regression model was constructed to associate cord blood metabolomics and demographic/physiological information to maternal obesity, with accuracy as high as 0.947. We identify 29 metabolites as early-life biomarkers manifesting intrauterine effect of maternal obesity.
Institute
University of Hawaii
DepartmentEpidemiology, Cancer Center
Last NameGarmire
First NameLana
Address701 Ilalo Street
EmailLgarmire@cc.hawaii.edu
PhoneNA
Submit Date2018-03-08
Num Groups2
Total Subjects57
Analysis Type DetailLC-MS
Release Date2019-01-22
Release Version1
Lana Garmire Lana Garmire
https://dx.doi.org/10.21228/M8CQ42
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

Select appropriate tab below to view additional metadata details:


Project:

Project ID:PR000745
Project DOI:doi: 10.21228/M8CQ42
Project Title:Cord blood metabolomics are associated with maternal pre-pregnant obesity in a prospective multi-ethnic cohort
Project Summary:na
Institute:University of Hawaii
Department:Epidemiology, Cancer Center
Last Name:Garmire
First Name:Lana
Address:701 Ilalo Street
Email:Lgarmire@cc.hawaii.edu
Phone:NA

Subject:

Subject ID:SU001159
Subject Type:Human
Subject Species:Homo sapiens
Taxonomy ID:9606

Factors:

Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id Weight
SA075916MT12Normal
SA075917MT45Normal
SA075918MT50Normal
SA075919MT42Normal
SA075920MT39Normal
SA075921MT36Normal
SA075922MT38Normal
SA075923MT51Normal
SA075924MT41Normal
SA075925MT58Normal
SA075926MT73Normal
SA075927MT77Normal
SA075928MT78Normal
SA075929MT68Normal
SA075930MT67Normal
SA075931MT35Normal
SA075932MT64Normal
SA075933MT65Normal
SA075934MT57Normal
SA075935MT44Normal
SA075936MT29Normal
SA075937MT28Normal
SA075938MT27Normal
SA075939MT20Normal
SA075940MT22Normal
SA075941MT23Normal
SA075942MT33Normal
SA075943MT19Normal
SA075944MT15Normal
SA075945MT63Obese
SA075946MT62Obese
SA075947MT66Obese
SA075948MT74Obese
SA075949MT16Obese
SA075950MT13Obese
SA075951MT76Obese
SA075952MT75Obese
SA075953MT18Obese
SA075954MT61Obese
SA075955MT69Obese
SA075956MT24Obese
SA075957MT43Obese
SA075958MT49Obese
SA075959MT26Obese
SA075960MT30Obese
SA075961MT31Obese
SA075962MT32Obese
SA075963MT40Obese
SA075964MT52Obese
SA075965MT53Obese
SA075966MT34Obese
SA075967MT59Obese
SA075968MT25Obese
SA075969MT56Obese
SA075970MT54Obese
SA075971MT55Obese
SA075972MT60Obese
Showing results 1 to 57 of 57

Collection:

Collection ID:CO001153
Collection Summary:NA
Sample Type:Blood (plasma)

Treatment:

Treatment ID:TR001173
Treatment Summary:NA

Sample Preparation:

Sampleprep ID:SP001166
Sampleprep Summary:NA

Combined analysis:

Analysis ID AN001810
Analysis type MS
Chromatography type Reversed phase
Chromatography system Waters Acquity
Column ACQUITY UPLC BEH C18 1.7µm
MS Type ESI
MS instrument type Triple quadrupole
MS instrument name Waters Xevo-TQ-S
Ion Mode POSITIVE
Units intensity

Chromatography:

Chromatography ID:CH001275
Instrument Name:Waters Acquity
Column Name:ACQUITY UPLC BEH C18 1.7µm
Column Temperature:35
Flow Rate:0.4 ml/min
Solvent A:Water + 0.1% formic acid
Solvent B:Acetonitrile + 0.1% formic acid
Analytical Time:6.6 min
Chromatography Type:Reversed phase

MS:

MS ID:MS001668
Analysis ID:AN001810
Instrument Name:Waters Xevo-TQ-S
Instrument Type:Triple quadrupole
MS Type:ESI
Ion Mode:POSITIVE
Capillary Temperature:150 °C
Capillary Voltage:3.9V
Collision Energy:20V
Collision Gas:0.17 mL/Min
Dry Gas Flow:150 L/Hr
Dry Gas Temp:350 °C
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