Summary of Study ST001828

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001155. The data can be accessed directly via it's Project DOI: 10.21228/M8DH5P This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST001828
Study TitleNested case–control study of environmental exposure within the ongoing Puerto Rico Testsite for Exploring Contamination Threats (PROTECT) pregnancy cohort.
Study TypeObservational
Study SummaryPreterm birth is the leading cause of infant mortality worldwide, and also greatly increases the risk of developing serious health complications in childhood and throughout life. Conditions that contribute to preterm birth remain largely unclear, though an influence by environmental exposures is suspected but poorly understood. In our preliminary work, we found that exposure to common chemicals, such as phthalates and bisphenol A (BPA), may contribute to this serious but understudied public health problem. We also observed strong associations between phthalates/BPA and general markers of oxidative stress, and in turn between these general markers of oxidative stress and risk of preterm birth. In this nested case-control study within an ongoing cohort of pregnant women in Puerto Rico (PROTECT), we will explore untargeted lipidomics, as well as levels of eicosanoids specific to arachidonic acid oxidation pathways, in relation to both environmental exposures and preterm birth.
Institute
University of Michigan
DepartmentMRC2
Last NameKachman
First NameMaureen
AddressAnn Arbor, MI, 48105, USA
Emailmkachman@med.umich.edu
Phone734-232-0842
Submit Date2021-06-11
Raw Data AvailableYes
Raw Data File Type(s)d
Analysis Type DetailLC-MS
Release Date2021-12-15
Release Version1
Maureen Kachman Maureen Kachman
https://dx.doi.org/10.21228/M8DH5P
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

Select appropriate tab below to view additional metadata details:


Project:

Project ID:PR001155
Project DOI:doi: 10.21228/M8DH5P
Project Title:Nested case–control study of environmental exposure within the ongoing Puerto Rico Testsite for Exploring Contamination Threats (PROTECT) pregnancy cohort.
Project Summary:Preterm birth is the leading cause of infant mortality worldwide, and also greatly increases the risk of developing serious health complications in childhood and throughout life. Conditions that contribute to preterm birth remain largely unclear, though an influence by environmental exposures is suspected but poorly understood. In our preliminary work, we found that exposure to common chemicals, such as phthalates and bisphenol A (BPA), may contribute to this serious but understudied public health problem. We also observed strong associations between phthalates/BPA and general markers of oxidative stress, and in turn between these general markers of oxidative stress and risk of preterm birth. In this nested case-control study within an ongoing cohort of pregnant women in Puerto Rico (PROTECT), we will explore untargeted lipidomics, as well as levels of eicosanoids specific to arachidonic acid oxidation pathways, in relation to both environmental exposures and preterm birth.
Institute:University of Michigan
Department:Nutritional Sciences
Laboratory:Meeker Lab
Last Name:Meeker
First Name:John
Address:Ann Arbor, MI
Email:meekerj@umich.edu
Phone:734-764-7184

Subject:

Subject ID:SU001905
Subject Type:Human
Subject Species:Homo sapiens
Taxonomy ID:9606

Factors:

Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id PRETERM BIRTH
SA169781Sample2605NO
SA169782Sample2603NO
SA169783Sample2599NO
SA169784Sample2608NO
SA169785Sample2622NO
SA169786Sample2794NO
SA169787Sample2765NO
SA169788Sample2597NO
SA169789Sample2609NO
SA169790Sample2590NO
SA169791Sample2580NO
SA169792Sample2578NO
SA169793Sample2577NO
SA169794Sample2582NO
SA169795Sample2584NO
SA169796Sample3002NO
SA169797Sample2589NO
SA169798Sample2585NO
SA169799Sample2591NO
SA169800Sample3080NO
SA169801Sample7023NO
SA169802Sample7013NO
SA169803Sample7012NO
SA169804Sample7037NO
SA169805Sample7045NO
SA169806Sample7130NO
SA169807Sample7121NO
SA169808Sample7118NO
SA169809Sample7001NO
SA169810Sample7000NO
SA169811Sample3082NO
SA169812Sample3081NO
SA169813Sample2576NO
SA169814Sample3083NO
SA169815Sample3116NO
SA169816Sample6019NO
SA169817Sample3123NO
SA169818Sample3117NO
SA169819Sample3079NO
SA169820Sample2592NO
SA169821Sample2172NO
SA169822Sample2166NO
SA169823Sample2149NO
SA169824Sample2573NO
SA169825Sample2207NO
SA169826Sample2310NO
SA169827Sample2305NO
SA169828Sample2144NO
SA169829Sample2125NO
SA169830Sample1006NO
SA169831Sample1001NO
SA169832Sample1042NO
SA169833Sample2012NO
SA169834Sample2044NO
SA169835Sample2038NO
SA169836Sample2319NO
SA169837Sample2177NO
SA169838Sample2555NO
SA169839Sample2551NO
SA169840Sample2329NO
SA169841Sample2339NO
SA169842Sample2350NO
SA169843Sample2324NO
SA169844Sample2344NO
SA169845Sample2320NO
SA169846Sample2558NO
SA169847Sample2321NO
SA169848Sample2342NO
SA169849Sample2327NO
SA169850Sample2037YES
SA169851Sample2017YES
SA169852Sample2010YES
SA169853Sample1019YES
SA169854Sample7138YES
SA169855Sample7141YES
SA169856Sample7148YES
SA169857Sample7128YES
SA169858Sample7122YES
SA169859Sample1021YES
SA169860Sample6021YES
SA169861Sample7115YES
SA169862Sample3144YES
SA169863Sample3037YES
SA169864Sample3059YES
SA169865Sample3061YES
SA169866Sample3034YES
SA169867Sample3012YES
SA169868Sample2680YES
SA169869Sample2792YES
SA169870Sample2284YES
SA169871Sample2325YES
SA169872Sample2596YES
SA169873Sample2616YES
SA169874Sample3146YES
SA169875Sample3156YES
SA169876Sample3136YES
SA169877Sample2128YES
SA169878Sample0002YES
SA169879Sample2135YES
SA169880Sample2115YES
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Collection:

Collection ID:CO001898
Collection Summary:Standard blood plasma collection protocol
Sample Type:Blood (plasma)
Storage Conditions:-80℃

Treatment:

Treatment ID:TR001918
Treatment Summary:This is an observational study, no specific treatment was applied.

Sample Preparation:

Sampleprep ID:SP001911
Sampleprep Summary:MRC2 untargeted metabolomics sample preparation protocol
Sampleprep Protocol Filename:Untargeted_metabolomics_analysis.DOC

Combined analysis:

Analysis ID AN002964 AN002965 AN002966 AN002967
Analysis type MS MS MS MS
Chromatography type Reversed phase Reversed phase Reversed phase Reversed phase
Chromatography system Agilent 1290 Infinity II Agilent 1290 Infinity II Agilent 1290 Infinity II Agilent 1290 Infinity II
Column Waters Acquity BEH C18 (100 x 2mm, 1.7um) Waters Acquity BEH C18 (100 x 2mm, 1.7um) Waters Acquity BEH C18 (100 x 2mm, 1.7um) Waters Acquity BEH C18 (100 x 2mm, 1.7um)
MS Type ESI ESI ESI ESI
MS instrument type QTOF QTOF QTOF QTOF
MS instrument name Agilent 6445 Q-TOF Agilent 6445 Q-TOF Agilent 6445 Q-TOF Agilent 6445 Q-TOF
Ion Mode POSITIVE POSITIVE NEGATIVE NEGATIVE
Units Peak area Peak area Peak area Peak area

Chromatography:

Chromatography ID:CH002197
Chromatography Summary:Positive mode RP
Instrument Name:Agilent 1290 Infinity II
Column Name:Waters Acquity BEH C18 (100 x 2mm, 1.7um)
Chromatography Type:Reversed phase
  
Chromatography ID:CH002198
Chromatography Summary:Negative mode RP
Instrument Name:Agilent 1290 Infinity II
Column Name:Waters Acquity BEH C18 (100 x 2mm, 1.7um)
Chromatography Type:Reversed phase

MS:

MS ID:MS002754
Analysis ID:AN002964
Instrument Name:Agilent 6445 Q-TOF
Instrument Type:QTOF
MS Type:ESI
MS Comments:Positive mode untargeted analysis
Ion Mode:POSITIVE
  
MS ID:MS002755
Analysis ID:AN002965
Instrument Name:Agilent 6445 Q-TOF
Instrument Type:QTOF
MS Type:ESI
MS Comments:Positive mode identified compounds
Ion Mode:POSITIVE
  
MS ID:MS002756
Analysis ID:AN002966
Instrument Name:Agilent 6445 Q-TOF
Instrument Type:QTOF
MS Type:ESI
MS Comments:Negative mode untargeted analysis
Ion Mode:NEGATIVE
  
MS ID:MS002757
Analysis ID:AN002967
Instrument Name:Agilent 6445 Q-TOF
Instrument Type:QTOF
MS Type:ESI
MS Comments:Negative mode identified compounds
Ion Mode:NEGATIVE
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