Studies involving disease:Malaria
| Study ID | Study Title | Species | Institute |
|---|---|---|---|
| ST000414 | Metabolomics-based screening of the Malaria Box reveals both novel and established mechanisms of action | Plasmodium falciparum | Monash Institute of Pharmaceutical Sciences |
| ST000441 | Metabolomic Profiling of the Malaria Box Reveals Antimalarial Target Pathways | Plasmodium falciparum | Pennsylvania State University |
| ST000546 | Multi-omics based identification of specific biochemical changes associated with PfKelch13-mutant artemisinin resistant Plasmodium | Plasmodium falciparum | Monash University |
| ST000578 | Experiment HuA: Metabolomics of plasma samples from humans infected with Plasmodium vivax strain. | Human | Emory University |
| ST000592 | Uninfected Macaca mulatta exposed to pyrimethamine to produce and integrate clinical, hematological, and omics control measures. | Rhesus monkey | Emory University |
| ST000599 | Metabolomics measures of Macaca mulatta infected with Plasmodium coatneyi Hackeri strain | Rhesus monkey | Emory University |
| ST001033 | Determination of mode of action of anti-malalrial drugs using untargeted metabolomics | Plasmodium falciparum | Monash University |
| ST001149 | Plasmodium Niemann-Pick Type C1-Related Protein is a Druggable Target Required for Parasite Membrane Homeostasis | Plasmodium falciparum | Pennsylvania State University |
| ST001175 | Multi-omics analysis demonstrates unique mode of action of a potent new antimalarial compound, JPC-3210, against Plasmodium falciparum | Plasmodium falciparum | Monash University |
| ST001188 | P. falciparum infected erythrocytes | Plasmodium falciparum | University of Melbourne |
| ST001201 | Peroxide antimalarial treatment timecourse on trophozoite-stage P. falciparum parasites | Human | Monash University |
| ST001201 | Peroxide antimalarial treatment timecourse on trophozoite-stage P. falciparum parasites | Plasmodium falciparum | Monash University |
| ST001202 | Peroxide antimalarial treatment timecourse on ring-stage P. falciparum parasites | Human | Monash University |
| ST001202 | Peroxide antimalarial treatment timecourse on ring-stage P. falciparum parasites | Plasmodium falciparum | Monash University |
| ST001204 | Peroxide antimalarial extended treatment timecourse on trophozoite-stage P. falciparum parasites | Human | Monash University |
| ST001204 | Peroxide antimalarial extended treatment timecourse on trophozoite-stage P. falciparum parasites | Plasmodium falciparum | Monash University |
| ST001205 | Peroxide antimalarial treatment of K13-mutant and -wildtype P. falciparum parasites | Human | Monash University |
| ST001205 | Peroxide antimalarial treatment of K13-mutant and -wildtype P. falciparum parasites | Plasmodium falciparum | Monash University |
| ST001232 | Combining stage - specificity and metabolomic profiling to advance drug discovery for malaria | Plasmodium falciparum | Pennsylvania State University |
| ST001238 | P falciparum asexual metabolomics following drug treatment (part-I) | Plasmodium falciparum | Pennsylvania State University |
| ST001239 | NMR assignment of synthetic pantothenamides (part-II) | Synthetic | Pennsylvania State University |
| ST001279 | K13 mutations driving artemisinin resistance rewrite Plasmodium falciparum’s programmed intra-erythrocytic development and transform mitochondrial physiology | Plasmodium falciparum | Pennsylvania State University |
| ST001315 | Retargeting azithromycin-like compounds as antimalarials with dual modality | Plasmodium falciparum | Monash University |
| ST001384 | Plasmodium falciparum increased time in circulation underlies persistent asymptomatic infection in the dry season | Human | Pennsylvania State University |
| ST001400 | Identification of distinct metabolic perturbations and associated immunomodulatory events during intra-erythrocytic development stage of pediatric Plasmodium falciparum malaria | Human | New York University Abu Dhabi |
| ST001516 | Identification of distinct metabolic perturbations and associated immunomodulatory events during intra-erythrocytic development stage of pediatric Plasmodium falciparum malaria (part-II) | Human | New York University Abu Dhabi |
| ST001517 | Identification of distinct metabolic perturbations and associated immunomodulatory events during intra-erythrocytic development stage of pediatric Plasmodium falciparum malaria (part-III) | Human | New York University Abu Dhabi |
| ST001652 | Atypical Molecular Basis for Drug Resistance to Mitochondrial AQ: A Function Inhibitors in Plasmodium falciparum | Plasmodium falciparum | U.S. Food & Drug Administration |
| ST001660 | Plasmodium falciparum metabolomics as a result of treatment with putative acetyl-CoA synthetase inhibitors | Fungi | Pennsylvania State University |
| ST001660 | Plasmodium falciparum metabolomics as a result of treatment with putative acetyl-CoA synthetase inhibitors | Plasmodium falciparum | Pennsylvania State University |
| ST001775 | Plasma metabolomics of diverse mouse strains infected with Plasmodium chabaudi | Mouse | Stanford University |
| ST001864 | Targeting host glycolysis as a strategy for antimalarial development | Human | University of Colorado Anschutz Medical Campus |
| ST001899 | Systemic host inflammation induces stage-specific transcriptomic modification and slower maturation in malaria parasites (part I) | Mouse | QIMR Berghofer Medical Research Institute |
| ST001900 | Systemic host inflammation induces stage-specific transcriptomic modification and slower maturation in malaria parasites (part II) | Mouse | QIMR Berghofer Medical Research Institute |
| ST001985 | Profiling Plasmodium falciparum parasites and human red blood cells after treatment with MMV693183 | Human | Pennsylvania State University |
| ST001985 | Profiling Plasmodium falciparum parasites and human red blood cells after treatment with MMV693183 | Plasmodium falciparum | Pennsylvania State University |
| ST002011 | The anticancer human mTOR inhibitor MLN0128/Sapanisertib with potent multistage in vitro antiplasmodium activity and in vivo antimalarial efficacy in a humanised mouse model is an inhibitor of multiple Plasmodium falciparum kinases. | Plasmodium falciparum | Pennsylvania State University |
| ST002024 | Plasmodium falciparum stable-isotope carbon labeling to explore metabolic consequences of keto–acid dehydrogenase disruption | Plasmodium falciparum | Pennsylvania State University |
| ST002078 | Multiple modes of interfering with the activity of Plasmodium falciparum cytoplasmic isoleucyl-tRNA synthetase illustrate the enzyme is a promising antimalarial target. | Plasmodium falciparum | Pennsylvania State University |
| ST002106 | Genetic and chemical validation of Plasmodium falciparum aminopeptidase PfA-M17 as a drug target in the hemoglobin digestion pathway (Part 1) | Plasmodium falciparum | Monash University |
| ST002107 | Genetic and chemical validation of Plasmodium falciparum aminopeptidase PfA-M17 as a drug target in the hemoglobin digestion pathway (Part 2) | Plasmodium falciparum | Monash University |
| ST002108 | Genetic and chemical validation of Plasmodium falciparum aminopeptidase PfA-M17 as a drug target in the hemoglobin digestion pathway (Part 3) | Plasmodium falciparum | Monash University |
| ST002181 | Piperaquine-resistant PfCRT mutations differentially impact drug transport, hemoglobin catabolism and parasite physiology in Plasmodium falciparum asexual blood stages. | Plasmodium falciparum | Pennsylvania State University |
| ST002309 | Targeting malaria parasites with novel derivatives of azithromycin | Plasmodium falciparum | Monash University |
| ST002698 | Systemic host inflammation induces stage-specific transcriptomic modification and slower maturation in malaria parasites | Plasmodium berghei | Peter Doherty Institute for Infection and Immunity |
| ST002792 | Chemoproteomics validates selective targeting of Plasmodium M1 alanyl aminopeptidase as a cross-species strategy to treat malaria | Plasmodium falciparum | Monash University |
| ST002926 | Multi-“omics” analysis reveals the orphan P. falciparum protein kinase PfPK8 regulates multi-gene family expression | Plasmodium falciparum | Monash University |
| ST003117 | Metabolomics of patients with Plasmodium vivax malaria | Human | University of Sao Paulo |
| ST003144 | On-target, dual aminopeptidase inhibition provides cross-species antimalarial activity | Plasmodium falciparum | Monash University |
| ST003160 | New class of heterospirocyclic compounds present strong and rapid activity against artemisinin- and multidrug-resistant P. falciparum parasites | Plasmodium falciparum | Monash University |
| ST003179 | Property and Activity Refinement of Dihydroquinazolinone-3-carboxamides as Orally Efficacious Antimalarials that Target PfATP4 | Plasmodium falciparum | Monash University |
| ST003224 | The Ataxia-Telangiectasia Mutated Kinase Inhibitor AZD0156 is a Potent Inhibitor of Plasmodium Phosphatidylinositol 4-Kinase and is an Attractive Candidate for Repositioning Against Malaria | Plasmodium falciparum | Pennsylvania State University |
| ST003440 | Non-targeted metabolomic analysis of Enterobacter hormaechei_B17 (Eh_B17),Enterobacter sichuanensis_B36(Es_B36), and Enterobacter hormaechei_B56 (Eh_B56) | Enterobacter sp. | Institute of Zoology, Chinese Academy of Sciences |
| ST003562 | Multiple, redundant carboxylic acid transporters support mitochondrial metabolism in Plasmodium falciparum | Plasmodium falciparum | Pennsylvania State University |
| ST003565 | Metaboloomics analysis of the antimalarial compound WEHI-1888504 (aka compound 59) in Plasmodium falciparum (3D7) infected red blood cells | Plasmodium falciparum | Monash University |
| ST003642 | Hexosamine Biosynthesis Disruption Impairs GPI Production and Arrests Plasmodium falciparum Growth at Schizont Stages | Plasmodium falciparum | Pennsylvania State University |
| ST003741 | A Metabolite-Based Resistance Mechanism Against Malaria | Human | European Molecular Biology Laboratory |
| ST003902 | Plasmodium falciparum plasmepsin copy number and piperaquine treatment have no effect of hemoglobin digestion | Plasmodium falciparum | Pennsylvania State University |
| ST003904 | Plasmodium falciparum plasmepsin copy number and piperaquine treatment have no effect of hemoglobin digestion - Negative Mode | Plasmodium falciparum | Pennsylvania State University |
| ST003906 | Neither Plasmodium falciparum Plasmepsin Copy Number Nor Piperaquine Treatment Impact Hemoglobin Digestion | Plasmodium falciparum | Pennsylvania State University |
| ST004194 | PfK13-associated artemisinin resistance slows drug activation and enhances antioxidant defence, which can be overcome with sulforaphane | Plasmodium falciparum | Monash University |
| ST004222 | Elucidating the source of elevated proline in APR parasites | Parasite | Broad Institute of MIT and Harvard |
| ST004233 | Validating the role of the arginine to proline biosynthetic pathway in the APR | Parasite | Broad Institute of MIT and Harvard |
| ST004239 | Labeled amino acid uptake from multiplexed isotope media | Parasite | Broad Institute of MIT and Harvard |
| ST004240 | PfApiAT2 loss of function leads to Adaptive Proline Response (APR) | Parasite | Broad Institute of MIT and Harvard |
| ST004244 | Parasites with a disrupted arginine to proline pathway can still mount an APR | Parasite | Broad Institute of MIT and Harvard |
| ST004290 | Metabolomics characterisation of Plasmodium falciparum response to plasmepsin V peptidomimetic inhibitors - 5 hour treatment | Plasmodium falciparum | Monash University |
| ST004291 | Metabolomics analysis of Plasmodium falciparum asexual-stage parasites treated with plasmepsin V peptidomimetics - 16 hour treatment | Plasmodium falciparum | Monash University |