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MGP000057

UniProt Annotations

Entry Information
Gene Nameadenylate cyclase 3
Protein EntryADCY3_HUMAN
UniProt IDO60266
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=O60266-1; Sequence=Displayed; Name=2; IsoId=O60266-2; Sequence=VSP_055813, VSP_055814, VSP_055815; Note=No experimental confirmation available.;
Catalytic ActivityATP = 3',5'-cyclic AMP + diphosphate.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Note=Binds 2 magnesium ions per subunit. {ECO:0000250};
Enzyme RegulationActivated by calcium/calmodulin.
FunctionMediates odorant detection (possibly) via modulation of intracellular cAMP concentration.
SimilarityBelongs to the adenylyl cyclase class-4/guanylyl cyclase family. {ECO:0000255|PROSITE-ProRule:PRU00099}.
SimilarityContains 2 guanylate cyclase domains. {ECO:0000255|PROSITE-ProRule:PRU00099}.
Subcellular LocationMembrane; Multi-pass membrane protein.
Tissue SpecificityExpressed in brain, heart, kidney, liver, lung, pancreas, placenta, and skeletal muscle.
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