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MGP000075

UniProt Annotations

Entry Information
Gene Nameadenosine A2a receptor
Protein EntryAA2AR_HUMAN
UniProt IDP29274
SpeciesHuman
Comments
Comment typeDescription
DomainThe cytoplasmic C-terminal domain is necessary for targeting the non-ubiquitinated form of this protein to the cell surface.
FunctionReceptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
InteractionSelf; NbExp=6; IntAct=EBI-2902702, EBI-2902702; P30542:ADORA1; NbExp=4; IntAct=EBI-2902702, EBI-2903663; P62158:CALM3; NbExp=3; IntAct=EBI-2902702, EBI-397435; Q99418:CYTH2; NbExp=6; IntAct=EBI-2902702, EBI-448974; P14416:DRD2; NbExp=2; IntAct=EBI-2902702, EBI-2928178; P31424-1:Grm5 (xeno); NbExp=3; IntAct=EBI-2902702, EBI-2902778; Q7Z6G3:NECAB2; NbExp=5; IntAct=EBI-2902702, EBI-950070; Q13107:USP4; NbExp=4; IntAct=EBI-2902702, EBI-723290;
PtmUbiquitinated. Deubiquitinated by USP4; leading to stabilization and expression at the cell surface. {ECO:0000269|PubMed:16339847}.
Sequence CautionSequence=AAA58356.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the G-protein coupled receptor 1 family. {ECO:0000255|PROSITE-ProRule:PRU00521}.
Subcellular LocationCell membrane; Multi-pass membrane protein.
SubunitInteracts (via cytoplasmic C-terminal domain) with USP4; the interaction is direct. May interact with DRD4. {ECO:0000269|PubMed:16339847, ECO:0000269|PubMed:18832607}.
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