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MGP000147

UniProt Annotations

Entry Information
Gene Nameangiopoietin 2
Protein EntryANGP2_HUMAN
UniProt IDO15123
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=O15123-1; Sequence=Displayed; Name=3; IsoId=O15123-2; Sequence=VSP_001540; Name=2; IsoId=O15123-3; Sequence=VSP_040096; Note=No experimental confirmation available.;
DomainThe Fibrinogen C-terminal domain mediates interaction with the TEK/TIE2 receptor.
FunctionBinds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. {ECO:0000269|PubMed:15284220, ECO:0000269|PubMed:19116766, ECO:0000269|PubMed:19223473, ECO:0000269|PubMed:9204896}.
InteractionQ02763:TEK; NbExp=4; IntAct=EBI-2912111, EBI-2257090;
SimilarityContains 1 fibrinogen C-terminal domain. {ECO:0000255|PROSITE-ProRule:PRU00739}.
Subcellular LocationSecreted.
SubunitInteracts with TEK/TIE2, competing for the same binding site as ANGPT1. {ECO:0000269|PubMed:12427764, ECO:0000269|PubMed:15284220, ECO:0000269|PubMed:16732286, ECO:0000269|PubMed:19223473, ECO:0000269|PubMed:9204896}.
Web ResourceName=Wikipedia; Note=Angiopoietin entry; URL="http://en.wikipedia.org/wiki/Angiopoietin";
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