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MGP000187

UniProt Annotations

Entry Information
Gene Nameaquaporin 7
Protein EntryAQP7_HUMAN
UniProt IDO14520
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=O14520-1; Sequence=Displayed; Name=2; IsoId=O14520-2; Sequence=VSP_056249, VSP_056250;
DomainAquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro/Ala-Ala/Ser (NPA).
FunctionForms a channel for water and glycerol.
PolymorphismGenetic variations in AQP7 are responsible for changes in glycerol release during exercise and define the glycerol quantitative trait locus (GLYCQTL) [MIM:614411].
SimilarityBelongs to the MIP/aquaporin (TC 1.A.8) family. {ECO:0000305}.
Subcellular LocationMembrane; Multi-pass membrane protein.
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