MGP Database

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MGP000265

UniProt Annotations

Entry Information
Gene NameATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
Protein EntryVATA_HUMAN
UniProt IDP38606
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P38606-1; Sequence=Displayed; Name=2; IsoId=P38606-2; Sequence=VSP_056408; Note=No experimental confirmation available.;
Catalytic ActivityATP + H(2)O + H(+)(In) = ADP + phosphate + H(+)(Out).
FunctionCatalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
SimilarityBelongs to the ATPase alpha/beta chains family. {ECO:0000305}.
SubunitV-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (main components: subunits A, B, C, D, E, and F) attached to an integral membrane V0 proton pore complex (main component: the proteolipid protein).
Tissue SpecificityPresent in all tissues analyzed.
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