MGP Database

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MGP000333

Ontology/Pathway Information

Entrez Gene ID673
Gene NameB-Raf proto-oncogene, serine/threonine kinase
Gene Symbol BRAF
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0044297 IEA:EnsemblCcell body
GO:0005829 TAS:ReactomeCcytosol
GO:0005739 IEA:EnsemblCmitochondrion
GO:0043005 IEA:EnsemblCneuron projection
GO:0005634 IEA:UniProtKB-SubCellCnucleus
GO:0005886 TAS:ReactomeCplasma membrane
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0005509 IDA:BHF-UCLFcalcium ion binding
GO:0042802 IPI:IntActFidentical protein binding
GO:0004709 IEA:EnsemblFMAP kinase kinase kinase activity
GO:0004672 IDA:BHF-UCLFprotein kinase activity
GO:0004674 IDA:UniProtKBFprotein serine/threonine kinase activity
GO:0000186 TAS:ReactomePactivation of MAPKK activity
GO:0043367 IEA:EnsemblPCD4-positive, alpha-beta T cell differentiation
GO:0071277 IDA:BHF-UCLPcellular response to calcium ion
GO:0035690 IEA:EnsemblPcellular response to drug
GO:0008543 TAS:ReactomePfibroblast growth factor receptor signaling pathway
GO:0060291 IEA:EnsemblPlong-term synaptic potentiation
GO:0002318 IEA:EnsemblPmyeloid progenitor cell differentiation
GO:0043066 IDA:UniProtKBPnegative regulation of apoptotic process
GO:2000352 IEA:EnsemblPnegative regulation of endothelial cell apoptotic process
GO:0010764 IEA:EnsemblPnegative regulation of fibroblast migration
GO:0043524 IEA:EnsemblPnegative regulation of neuron apoptotic process
GO:2000301 IEA:EnsemblPnegative regulation of synaptic vesicle exocytosis
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0009887 TAS:ProtIncPorgan morphogenesis
GO:0070374 IDA:BHF-UCLPpositive regulation of ERK1 and ERK2 cascade
GO:0010628 IMP:BHF-UCLPpositive regulation of gene expression
GO:0033138 IDA:UniProtKBPpositive regulation of peptidyl-serine phosphorylation
GO:0051496 IEA:EnsemblPpositive regulation of stress fiber assembly
GO:1900026 IEA:EnsemblPpositive regulation of substrate adhesion-dependent cell spreading
GO:0043368 IEA:EnsemblPpositive T cell selection
GO:0051291 IEA:EnsemblPprotein heterooligomerization
GO:0006468 IDA:BHF-UCLPprotein phosphorylation
GO:0042127 IEA:EnsemblPregulation of cell proliferation
GO:0051591 IEA:EnsemblPresponse to cAMP
GO:0070849 IEA:EnsemblPresponse to epidermal growth factor
GO:0043434 IEA:EnsemblPresponse to peptide hormone
GO:0007264 TAS:ReactomePsmall GTPase mediated signal transduction
GO:0035019 IEA:EnsemblPsomatic stem cell maintenance
GO:0007268 TAS:ReactomePsynaptic transmission
GO:0008542 IEA:EnsemblPvisual learning
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_20563Activation of NMDA receptor upon glutamate binding and postsynaptic events
REACT_12002ARMS-mediated activation
REACT_20568CREB phosphorylation through the activation of Ras
REACT_116125Disease
REACT_12076Frs2-mediated activation
REACT_111184Negative regulation of FGFR signaling
REACT_13685Neuronal System
REACT_15370Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_20593Post NMDA receptor activation events
REACT_12005Prolonged ERK activation events
REACT_9470Signaling by FGFR
REACT_120736Signaling by FGFR in disease
REACT_11061Signalling by NGF
REACT_12058Signalling to ERKs
REACT_12077Signalling to p38 via RIT and RIN
REACT_111102Signal Transduction
REACT_111080Spry regulation of FGF signaling
REACT_13477Transmission across Chemical Synapses
SMP Pathway Links
SMP IDDescription
SMP00320Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
SMP00321Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
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