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MGP000394

UniProt Annotations

Entry Information
Gene Namecalcitonin receptor
Protein EntryCALCR_HUMAN
UniProt IDP30988
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative promoter usage, Alternative splicing; Named isoforms=6; Name=1; IsoId=P30988-1; Sequence=Displayed; Name=2; IsoId=P30988-2; Sequence=VSP_053290, VSP_053291; Name=3; IsoId=P30988-3; Sequence=VSP_053289, VSP_053291; Name=4; Synonyms=Delta(1-47)hCT((a)); IsoId=P30988-4; Sequence=VSP_053289; Name=5; Synonyms=HCTR-5; IsoId=P30988-5; Sequence=VSP_053290, VSP_053292, VSP_053293; Name=6; Synonyms=HCTR-6; IsoId=P30988-6; Sequence=VSP_053290, VSP_053291, VSP_053292, VSP_053293;
FunctionThis is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin.
PolymorphismGenetic variations in CALCR may be correlated with bone mineral density (BMD). Low BMD is a risk factor for osteoporotic fracture. Osteoporosis is characterized by reduced bone mineral density, disrutption of bone microarchitecture, and the alteration of the amount and variety of non-collagenous proteins in bone. Osteoporotic bones are more at risk of fracture.
Sequence CautionSequence=AAA35640.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
SimilarityBelongs to the G-protein coupled receptor 2 family. {ECO:0000305}.
Subcellular LocationCell membrane; Multi-pass membrane protein.
SubunitInteracts with GPRASP2. {ECO:0000269|PubMed:15086532}.
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