MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP000415

Ontology/Pathway Information

Entrez Gene ID836
Gene Namecaspase 3, apoptosis-related cysteine peptidase
Gene Symbol CASP3
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005829 IDA:UniProtKBCcytosol
GO:0005654 TAS:ReactomeCnucleoplasm
GO:0005634 IDA:UniProtKBCnucleus
GO:0005886 TAS:ReactomeCplasma membrane
GO:0004190 EXP:ReactomeFaspartic-type endopeptidase activity
GO:0004861 IEA:EnsemblFcyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0004197 IDA:UniProtKBFcysteine-type endopeptidase activity
GO:0097153 IMP:UniProtKBFcysteine-type endopeptidase activity involved in apoptotic process
GO:0097200 IMP:UniProtKBFcysteine-type endopeptidase activity involved in execution phase of apoptosis
GO:0008233 IDA:UniProtKBFpeptidase activity
GO:0008635 TAS:ReactomePactivation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0006309 TAS:ReactomePapoptotic DNA fragmentation
GO:0006915 TAS:ReactomePapoptotic process
GO:0097190 TAS:BHF-UCLPapoptotic signaling pathway
GO:0001782 IEA:EnsemblPB cell homeostasis
GO:0045165 IEA:EnsemblPcell fate commitment
GO:0006921 TAS:ReactomePcellular component disassembly involved in execution phase of apoptosis
GO:0006974 IEA:EnsemblPcellular response to DNA damage stimulus
GO:0030218 IDA:UniProtKBPerythrocyte differentiation
GO:0097194 IDA:UniProtKBPexecution phase of apoptosis
GO:0022617 TAS:ReactomePextracellular matrix disassembly
GO:0030198 TAS:ReactomePextracellular matrix organization
GO:0097192 IEA:EnsemblPextrinsic apoptotic signaling pathway in absence of ligand
GO:0008625 IEA:EnsemblPextrinsic apoptotic signaling pathway via death domain receptors
GO:0034349 IEA:EnsemblPglial cell apoptotic process
GO:0007507 IEA:EnsemblPheart development
GO:0035329 TAS:ReactomePhippo signaling
GO:0097193 TAS:ReactomePintrinsic apoptotic signaling pathway
GO:0008631 IEA:EnsemblPintrinsic apoptotic signaling pathway in response to oxidative stress
GO:0030216 IBA:GO_CentralPkeratinocyte differentiation
GO:0046007 IEA:EnsemblPnegative regulation of activated T cell proliferation
GO:0043066 IGI:MGIPnegative regulation of apoptotic process
GO:0030889 IEA:EnsemblPnegative regulation of B cell proliferation
GO:0045736 IEA:EnsemblPnegative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0051402 IEA:EnsemblPneuron apoptotic process
GO:0030182 IBA:GO_CentralPneuron differentiation
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0030220 TAS:UniProtKBPplatelet formation
GO:0043065 TAS:ReactomePpositive regulation of apoptotic process
GO:0043525 IEA:EnsemblPpositive regulation of neuron apoptotic process
GO:0006508 IDA:UniProtKBPproteolysis
GO:1902510 IEA:EnsemblPregulation of apoptotic DNA fragmentation
GO:0042981 TAS:ReactomePregulation of apoptotic process
GO:0043281 TAS:ReactomePregulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0001836 IEA:EnsemblPrelease of cytochrome c from mitochondria
GO:0034612 TAS:BHF-UCLPresponse to tumor necrosis factor
GO:0009411 IEA:EnsemblPresponse to UV
GO:0009611 IEA:EnsemblPresponse to wounding
GO:0007605 IEA:EnsemblPsensory perception of sound
GO:0043029 IEA:EnsemblPT cell homeostasis
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_607Activation of caspases through apoptosome-mediated cleavage
REACT_13462Activation of DNA fragmentation factor
REACT_578Apoptosis
REACT_1213Apoptosis induced DNA fragmentation
REACT_13579Apoptotic cleavage of cell adhesion proteins
REACT_107Apoptotic cleavage of cellular proteins
REACT_995Apoptotic execution phase
REACT_963Apoptotic factor-mediated response
REACT_13541Caspase-mediated cleavage of cytoskeletal proteins
REACT_13720Cell death signalling via NRAGE, NRIF and NADE
REACT_831Cytochrome c-mediated apoptotic response
REACT_118572Degradation of the extracellular matrix
REACT_118779Extracellular matrix organization
REACT_1059Extrinsic Pathway
REACT_964Intrinsic Pathway for Apoptosis
REACT_13526NADE modulates death signalling
REACT_13776p75 NTR receptor-mediated signalling
REACT_268456Programmed Cell Death
REACT_22128Role of DCC in regulating apoptosis
REACT_118607Signaling by Hippo
REACT_11061Signalling by NGF
REACT_111102Signal Transduction
REACT_2190SMAC binds to IAPs
REACT_666SMAC-mediated apoptotic response
REACT_1767SMAC-mediated dissociation of IAP:caspase complexes
REACT_13532Stimulation of the cell death response by PAK-2p34
  logo