MGP Database

MGP000427

Ontology/Pathway Information

Entrez Gene ID	860
Gene Name	runt-related transcription factor 2
Gene Symbol	RUNX2
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005737	IEA:Ensembl	C	cytoplasm
GO:0000790	ISS:BHF-UCL	C	nuclear chromatin
GO:0005634	IDA:HPA	C	nucleus
GO:0005667	IEA:Ensembl	C	transcription factor complex
GO:0005524	IEA:InterPro	F	ATP binding
GO:0003682	IEA:Ensembl	F	chromatin binding
GO:0003700	NAS:ProtInc	F	sequence-specific DNA binding transcription factor activity
GO:0044212	IEA:Ensembl	F	transcription regulatory region DNA binding
GO:0030509	ISS:BHF-UCL	P	BMP signaling pathway
GO:0048469	IEA:Ensembl	P	cell maturation
GO:0071773	ISS:BHF-UCL	P	cellular response to BMP stimulus
GO:0002063	IEA:Ensembl	P	chondrocyte development
GO:0048701	IEA:Ensembl	P	embryonic cranial skeleton morphogenesis
GO:0035115	IEA:Ensembl	P	embryonic forelimb morphogenesis
GO:0001958	IEA:Ensembl	P	endochondral ossification
GO:0010467	TAS:Reactome	P	gene expression
GO:0045879	IEA:Ensembl	P	negative regulation of smoothened signaling pathway
GO:0045892	IDA:UniProtKB	P	negative regulation of transcription, DNA-templated
GO:0042475	IEA:Ensembl	P	odontogenesis of dentin-containing tooth
GO:0001503	TAS:UniProtKB	P	ossification
GO:0002076	IEA:Ensembl	P	osteoblast development
GO:0001649	IEP:UniProtKB	P	osteoblast differentiation
GO:0002051	IEA:Ensembl	P	osteoblast fate commitment
GO:0008284	IEA:Ensembl	P	positive regulation of cell proliferation
GO:0032332	IEA:Ensembl	P	positive regulation of chondrocyte differentiation
GO:0045669	IEA:Ensembl	P	positive regulation of osteoblast differentiation
GO:0045893	IDA:UniProtKB	P	positive regulation of transcription, DNA-templated
GO:1901522	ISS:BHF-UCL	P	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
GO:0040036	IEA:Ensembl	P	regulation of fibroblast growth factor receptor signaling pathway
GO:0042487	IEA:Ensembl	P	regulation of odontogenesis of dentin-containing tooth
GO:0048863	IEA:Ensembl	P	stem cell differentiation
GO:0030217	IEA:Ensembl	P	T cell differentiation
GO:0006367	TAS:Reactome	P	transcription initiation from RNA polymerase II promoter

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_71	Gene Expression
REACT_12627	Generic Transcription Pathway
REACT_118713	YAP1- and WWTR1 (TAZ)-stimulated gene expression