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MGP000484

UniProt Annotations

Entry Information
Gene Namecell division cycle 25B
Protein EntryMPIP2_HUMAN
UniProt IDP30305
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=3; Synonyms=CDC25B3; IsoId=P30305-1; Sequence=Displayed; Name=1; Synonyms=CDC25B1; IsoId=P30305-2; Sequence=VSP_000861; Name=2; Synonyms=CDC25B2; IsoId=P30305-3; Sequence=VSP_000862; Name=4; IsoId=P30305-4; Sequence=VSP_000861, VSP_012587; Note=No experimental confirmation available.;
Catalytic ActivityProtein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
Enzyme RegulationStimulated by B-type cyclins.
FunctionTyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Directly dephosphorylates CDK1 and stimulates its kinase activity. The three isoforms seem to have a different level of activity. {ECO:0000269|PubMed:17332740}.
InteractionP31946:YWHAB; NbExp=4; IntAct=EBI-1051746, EBI-359815; Q04917:YWHAH; NbExp=3; IntAct=EBI-1051746, EBI-306940; P63104:YWHAZ; NbExp=4; IntAct=EBI-1051746, EBI-347088;
PtmPhosphorylated by BRSK1 in vitro. Phosphorylated by CHEK1, which inhibits the activity of this protein. Phosphorylation at Ser-353 by AURKA might locally participate in the control of the onset of mitosis. Phosphorylation by MELK at Ser-169 promotes localization to the centrosome and the spindle poles during mitosis. Phosphorylation at Ser-323 and Ser-375 by MAPK14 is required for binding to 14-3-3 proteins. {ECO:0000269|PubMed:11333986, ECO:0000269|PubMed:12400006, ECO:0000269|PubMed:15128871, ECO:0000269|PubMed:15150265, ECO:0000269|PubMed:15311285, ECO:0000269|PubMed:15629715, ECO:0000269|PubMed:15908796, ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:19690332}.
SimilarityBelongs to the MPI phosphatase family. {ECO:0000305}.
SimilarityContains 1 rhodanese domain. {ECO:0000255|PROSITE- ProRule:PRU00173}.
Subcellular LocationCytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole.
SubunitInteracts with MAPK14 and 14-3-3 proteins. {ECO:0000269|PubMed:11333986}.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/cdc25b/";
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