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MGP Database

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MGP000498

UniProt Annotations

Entry Information

Gene Name	cadherin 10, type 2 (T2-cadherin)
Protein Entry	CAD10_HUMAN
UniProt ID	Q9Y6N8
Species	Human

Comments

Comment type	Description
Domain	Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain. {ECO:0000250}.
Function	Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
Similarity	Contains 5 cadherin domains. {ECO:0000255\|PROSITE- ProRule:PRU00043}.
Subcellular Location	Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Tissue Specificity	Predominantly expressed in brain. Also found in adult and fetal kidney. Very low levels detected in prostate and fetal lung. {ECO:0000269\|PubMed:10386616}.