MGP Database

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MGP000510

Ontology/Pathway Information

Entrez Gene ID1024
Gene Namecyclin-dependent kinase 8
Gene Symbol CDK8
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0016592 IDA:MGICmediator complex
GO:0005654 TAS:ReactomeCnucleoplasm
GO:0005634 IDA:MGICnucleus
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0004693 IEA:UniProtKB-ECFcyclin-dependent protein serine/threonine kinase activity
GO:0004672 TAS:ProtIncFprotein kinase activity
GO:0008353 IEA:UniProtKB-ECFRNA polymerase II carboxy-terminal domain kinase activity
GO:0010467 TAS:ReactomePgene expression
GO:0007219 TAS:ReactomePNotch signaling pathway
GO:0045944 TAS:ReactomePpositive regulation of transcription from RNA polymerase II promoter
GO:0006351 TAS:ReactomePtranscription, DNA-templated
GO:0006367 TAS:ReactomePtranscription initiation from RNA polymerase II promoter
GO:0007179 TAS:ReactomePtransforming growth factor beta receptor signaling pathway
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_160254Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
REACT_160243Constitutive Signaling by NOTCH1 PEST Domain Mutants
REACT_111045Developmental Biology
REACT_116125Disease
REACT_22279Fatty acid, triacylglycerol, and ketone body metabolism
REACT_160099FBXW7 Mutants and NOTCH1 in Cancer
REACT_71Gene Expression
REACT_12627Generic Transcription Pathway
REACT_169398Loss of Function of SMAD2/3 in Cancer
REACT_169219Loss of Function of SMAD4 in Cancer
REACT_169311Loss of Function of TGFBR1 in Cancer
REACT_169435Loss of Function of TGFBR2 in Cancer
REACT_111217Metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_118780NOTCH1 Intracellular Domain Regulates Transcription
REACT_116145PPARA activates gene expression
REACT_19241Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
REACT_299Signaling by NOTCH
REACT_118859Signaling by NOTCH1
REACT_160133Signaling by NOTCH1 HD Domain Mutants in Cancer
REACT_160248Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
REACT_160214Signaling by NOTCH1 in Cancer
REACT_160301Signaling by NOTCH1 PEST Domain Mutants in Cancer
REACT_160082Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
REACT_6844Signaling by TGF-beta Receptor Complex
REACT_169122Signaling by TGF-beta Receptor Complex in Cancer
REACT_111102Signal Transduction
REACT_169165SMAD2/3 MH2 Domain Mutants in Cancer
REACT_169103SMAD2/3 Phosphorylation Motif Mutants in Cancer
REACT_120734SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
REACT_169107SMAD4 MH2 Domain Mutants in Cancer
REACT_169263TGFBR1 KD Mutants in Cancer
REACT_169445TGFBR1 LBD Mutants in Cancer
REACT_169440TGFBR2 Kinase Domain Mutants in Cancer
REACT_169192TGFBR2 MSI Frameshift Mutants in Cancer
REACT_121061Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
REACT_27161Transcriptional regulation of white adipocyte differentiation
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