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MGP000524

Record overview

MGPD IDMGP000524
Gene ID1058
SpeciesHomo sapiens (Human)
Gene Namecentromere protein A
Gene Symbol CENPA
SynonymsCenH3; CENP-A;
Alternate nameshistone H3-like centromeric protein A; centromere autoantigen A; centromere protein A, 17kDa; centromere-specific histone;
Chromosome2
Map Location2p23.3
SummaryCentromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. CENPA encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for CENPA

Proteins

histone H3-like centromeric protein A isoform a
Refseq ID:NP_001800
Protein GI:4502775
UniProt ID:P49450
mRNA ID:NM_001809
Length:140
RefSeq Status:
MGPRRRSRKPEAPRRRSPSPTPTPGPSRRGPSLGASSHQHSRRRQGWLKEIRKLQKSTHLLIRKLPFSRLAREICVKFTRGVDFNWQAQALLALQEAAEA
FLVHLFEDAYLLTLHAGRVTLFPKDVQLARRIRGLEEGLG
 
histone H3-like centromeric protein A isoform b
Refseq ID:NP_001035891
Protein GI:109637779
UniProt ID:P49450
mRNA ID:NM_001042426
Length:114
RefSeq Status:
MGPRRRSRKPEAPRRRSPSPTPTPGPSRRGPSLGASSHQHSRRRQGWLKEIRKLQKSTHLLIRKLPFSRLAAEAFLVHLFEDAYLLTLHAGRVTLFPKDV
QLARRIRGLEEGLG
 
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