MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP000576

Record overview

MGPD IDMGP000576
Gene ID1175
SpeciesHomo sapiens (Human)
Gene Nameadaptor-related protein complex 2, sigma 1 subunit
Gene Symbol AP2S1
SynonymsAP17; FBH3; HHC3; FBHOk; CLAPS2;
Alternate namesAP-2 complex subunit sigma; sigma2-adaptin; HA2 17 kDa subunit; clathrin coat assembly protein AP17; clathrin coat-associated protein AP17; adaptor protein complex AP-2 subunit sigma; plasma membrane adaptor AP-2 17 kDa protein; clathrin assembly protein 2 sigma small chain; clathrin-associated/assembly/adaptor protein, small 2 (17kD);
Chromosome19
Map Location19q13.2-q13.3
SummaryOne of two major clathrin-associated adaptor complexes, AP-2, is a heterotetramer which is associated with the plasma membrane. This complex is composed of two large chains, a medium chain, and a small chain. This gene encodes the small chain of this complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
OrthologsView orthologs and multiple alignments for AP2S1

Proteins

AP-2 complex subunit sigma isoform 3
Refseq ID:NP_001288005
Protein GI:666637993
UniProt ID:P53680
mRNA ID:NM_001301076
Length:158
RefSeq Status:
MKLKGLGKRCKRREDLEIRFILIQNRAGKTRLAKWYMQFDDDEKQKLIEEVHAVVTVRDAKHTNFVEFRNFKIIYRRYAGLYFCICVDVNDNNLAYLEAI
HNFVEVLNEYFHNVCELDLVFNFYKVYTVVDEMFLAGEIRETSQTKVLKQLLMLQSLE
 
AP-2 complex subunit sigma isoform 4
Refseq ID:NP_001288007
Protein GI:666637995
UniProt ID:P53680
mRNA ID:NM_001301078
Length:156
RefSeq Status:
MIRFILIQNRAGKTRLAKWYMQFDDDEKQKLIEEVHAVVTVRDAKHTNFVEVLAISVADSLSVLQFRNFKIIYRRYAGLYFCICVDVNDNNLAYLEAIHN
FVEVLNEYFHNVCELDLVFNFYKVYTVVDEMFLAGEIRETSQTKVLKQLLMLQSLE
 
AP-2 complex subunit sigma isoform 5
Refseq ID:NP_001288010
Protein GI:666637997
UniProt ID:P53680
mRNA ID:NM_001301081
Length:144
RefSeq Status:
MVWIRFILIQNRAGKTRLAKWYMQFDDDEKQKLIEEVHAVVTVRDAKHTNFVEFRNFKIIYRRYAGLYFCICVDVNDNNLAYLEAIHNFVEVLNEYFHNV
CELDLVFNFYKVYTVVDEMFLAGEIRETSQTKVLKQLLMLQSLE
 
AP-2 complex subunit sigma isoform AP17
Refseq ID:NP_004060
Protein GI:70906430
UniProt ID:P53680
mRNA ID:NM_004069
Length:142
RefSeq Status:
MIRFILIQNRAGKTRLAKWYMQFDDDEKQKLIEEVHAVVTVRDAKHTNFVEFRNFKIIYRRYAGLYFCICVDVNDNNLAYLEAIHNFVEVLNEYFHNVCE
LDLVFNFYKVYTVVDEMFLAGEIRETSQTKVLKQLLMLQSLE
 
AP-2 complex subunit sigma isoform AP17delta
Refseq ID:NP_067586
Protein GI:11038643
UniProt ID:P53680
mRNA ID:NM_021575
Length:104
RefSeq Status:
MIRFILIQNRAGKTRLAKWYMQFDDDEKQKLIEEVHAVVTVRDAKHTNFVEVLNEYFHNVCELDLVFNFYKVYTVVDEMFLAGEIRETSQTKVLKQLLML
QSLE
 
  logo