MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP000581

UniProt Annotations

Entry Information
Gene Namechloride channel, voltage-sensitive 3
Protein EntryCLCN3_HUMAN
UniProt IDP51790
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1; Synonyms=ClC-3A; IsoId=P51790-1; Sequence=Displayed; Name=2; Synonyms=ClC-3B; IsoId=P51790-2; Sequence=VSP_016073; Name=3; IsoId=P51790-4; Sequence=VSP_045105; Name=4; IsoId=P51790-5; Sequence=VSP_054415; Note=No experimental confirmation available.;
DomainIsoform 2 contains a C-terminal PDZ-binding motif mediating the interaction with GOPC. {ECO:0000269|PubMed:11967229}.
FunctionMediates the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the endosome and synaptic vesicle lumen, and may thereby affect vesicle trafficking and exocytosis. May play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C. It could help neuronal cells to establish short-term memory. {ECO:0000269|PubMed:11967229}.
MiscellaneousThe CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters (By similarity). {ECO:0000250}.
PtmN-glycosylated. {ECO:0000269|PubMed:11274166, ECO:0000269|PubMed:12471024}.
Sequence CautionSequence=BAC54560.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA55281.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
SimilarityBelongs to the chloride channel (TC 2.A.49) family. ClC-3/CLCN3 subfamily. {ECO:0000305}.
SimilarityContains 2 CBS domains. {ECO:0000255|PROSITE- ProRule:PRU00703}.
Subcellular LocationIsoform 1: Membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Isoform 1 is localized mainly in early and late endosomes.
Subcellular LocationIsoform 2: Membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Note=Isoform 2 partially colocalized with isoform 1 but is mainly enriched in the Golgi.
SubunitHomo- or heterodimer. Isoform 2 interacts with GOPC, PDZK1 and SLC9A3R1/EBP50. {ECO:0000269|PubMed:11967229, ECO:0000269|PubMed:12471024}.
Tissue SpecificityExpressed primarily in tissues derived from neuroectoderm. Within the brain, its expression is particularly evident in the hippocampus, olfactory cortex, and olfactory bulb. Highly expressed in aortic and coronary vascular smooth muscle cells, and aortic endothelial cells. Also expressed in tracheal and alveolar epithelial cells, and intima and media of the pulmonary vessels. Expressed in bronchus and colon (at protein level). {ECO:0000269|PubMed:10198195, ECO:0000269|PubMed:11967229, ECO:0000269|PubMed:12471024}.
  logo