MGP Database

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MGP000637

UniProt Annotations

Entry Information
Gene Namecollagen, type XII, alpha 1
Protein EntryCOCA1_HUMAN
UniProt IDQ99715
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Comment=The final tissue form of collagen XII may contain homotrimers of either isoform 1 or isoform 2 or any combination of isoform 1 and isoform 2.; Name=1; Synonyms=Long; IsoId=Q99715-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=Q99715-2; Sequence=VSP_001149; Name=4; IsoId=Q99715-4; Sequence=VSP_024942;
FunctionType XII collagen interacts with type I collagen- containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix. {ECO:0000250}.
PtmHydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates. {ECO:0000250}.
PtmIsoform 1 O-glycosylation; glycosaminoglycan of chondroitin- sulfate type. {ECO:0000250}.
PtmThe triple-helical tail is stabilized by disulfide bonds at each end. {ECO:0000250}.
SimilarityBelongs to the fibril-associated collagens with interrupted helices (FACIT) family. {ECO:0000305}.
SimilarityContains 18 fibronectin type-III domains. {ECO:0000255|PROSITE-ProRule:PRU00316}.
SimilarityContains 1 laminin G-like domain. {ECO:0000305}.
SimilarityContains 4 collagen-like domains. {ECO:0000305}.
SimilarityContains 4 VWFA domains. {ECO:0000255|PROSITE- ProRule:PRU00219}.
Subcellular LocationSecreted, extracellular space, extracellular matrix {ECO:0000250}.
SubunitTrimer of identical chains each containing 190 kDa of non-triple-helical sequences.
Tissue SpecificityFound in collagen I-containing tissues: both isoform 1 and isoform 2 appear in amnion, chorion, skeletal muscle, small intestine, and in cell culture of dermal fibroblasts, keratinocytes and endothelial cells. Only isoform 2 is found in lung, placenta, kidney and a squamous cell carcinoma cell line. Isoform 1 is also present in the corneal epithelial Bowman's membrane (BM) and the interfibrillar matrix of the corneal stroma, but it is not detected in the limbal BM. {ECO:0000269|PubMed:9344363}.
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