MGP Database

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MGP000693

Ontology/Pathway Information

Entrez Gene ID1432
Gene Namemitogen-activated protein kinase 14
Gene Symbol MAPK14
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 ISS:UniProtKBCcytoplasm
GO:0005829 TAS:ReactomeCcytosol
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0005739 IEA:EnsemblCmitochondrion
GO:0005654 IDA:HPACnucleoplasm
GO:0005634 ISS:UniProtKBCnucleus
GO:0000922 IEA:EnsemblCspindle pole
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0004707 IDA:UniProtKBFMAP kinase activity
GO:0004708 TAS:ProtIncFMAP kinase kinase activity
GO:0051525 ISS:BHF-UCLFNFAT protein binding
GO:0004674 TAS:ReactomeFprotein serine/threonine kinase activity
GO:0070935 TAS:UniProtKBP3'-UTR-mediated mRNA stabilization
GO:0000187 TAS:ReactomePactivation of MAPK activity
GO:0001525 IEA:EnsemblPangiogenesis
GO:0006915 IEA:UniProtKB-KWPapoptotic process
GO:0007596 TAS:ReactomePblood coagulation
GO:0001502 IEA:EnsemblPcartilage condensation
GO:0000902 IEA:EnsemblPcell morphogenesis
GO:0007166 TAS:ProtIncPcell surface receptor signaling pathway
GO:0006928 TAS:ProtIncPcellular component movement
GO:0071479 IMP:BHF-UCLPcellular response to ionizing radiation
GO:0071222 IDA:MGIPcellular response to lipopolysaccharide
GO:0035924 IMP:BHF-UCLPcellular response to vascular endothelial growth factor stimulus
GO:0006935 TAS:ProtIncPchemotaxis
GO:0002062 IEA:EnsemblPchondrocyte differentiation
GO:0000077 IEA:EnsemblPDNA damage checkpoint
GO:0019395 IEA:EnsemblPfatty acid oxidation
GO:0010467 TAS:ReactomePgene expression
GO:0006006 IEA:EnsemblPglucose metabolic process
GO:0045087 TAS:ReactomePinnate immune response
GO:0035556 IDA:UniProtKBPintracellular signal transduction
GO:0031663 IEA:EnsemblPlipopolysaccharide-mediated signaling pathway
GO:0016071 TAS:ReactomePmRNA metabolic process
GO:0042692 TAS:ReactomePmuscle cell differentiation
GO:0002755 TAS:ReactomePMyD88-dependent toll-like receptor signaling pathway
GO:0002756 TAS:ReactomePMyD88-independent toll-like receptor signaling pathway
GO:0014835 IEA:EnsemblPmyoblast differentiation involved in skeletal muscle regeneration
GO:0090090 IEA:EnsemblPnegative regulation of canonical Wnt signaling pathway
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0030316 ISS:BHF-UCLPosteoclast differentiation
GO:0038066 ISS:UniProtKBPp38MAPK cascade
GO:0018105 ISS:BHF-UCLPpeptidyl-serine phosphorylation
GO:0030168 TAS:ReactomePplatelet activation
GO:0045648 IEA:EnsemblPpositive regulation of erythrocyte differentiation
GO:0051149 TAS:ReactomePpositive regulation of muscle cell differentiation
GO:0045663 ISS:UniProtKBPpositive regulation of myoblast differentiation
GO:1901741 ISS:UniProtKBPpositive regulation of myoblast fusion
GO:0010831 ISS:UniProtKBPpositive regulation of myotube differentiation
GO:0042307 IEA:EnsemblPpositive regulation of protein import into nucleus
GO:2000379 IMP:BHF-UCLPpositive regulation of reactive oxygen species metabolic process
GO:0045944 IEA:EnsemblPpositive regulation of transcription from RNA polymerase II promoter
GO:0007265 TAS:ReactomePRas protein signal transduction
GO:0051090 TAS:ReactomePregulation of sequence-specific DNA binding transcription factor activity
GO:0006357 ISS:UniProtKBPregulation of transcription from RNA polymerase II promoter
GO:0032495 IEA:EnsemblPresponse to muramyl dipeptide
GO:0016070 TAS:ReactomePRNA metabolic process
GO:0007165 TAS:ProtIncPsignal transduction
GO:0042770 IMP:BHF-UCLPsignal transduction in response to DNA damage
GO:0007519 IEA:EnsemblPskeletal muscle tissue development
GO:0051403 TAS:ReactomePstress-activated MAPK cascade
GO:0090400 IMP:BHF-UCLPstress-induced premature senescence
GO:0051146 IEA:EnsemblPstriated muscle cell differentiation
GO:0034166 TAS:ReactomePtoll-like receptor 10 signaling pathway
GO:0034134 TAS:ReactomePtoll-like receptor 2 signaling pathway
GO:0034138 TAS:ReactomePtoll-like receptor 3 signaling pathway
GO:0034142 TAS:ReactomePtoll-like receptor 4 signaling pathway
GO:0034146 TAS:ReactomePtoll-like receptor 5 signaling pathway
GO:0034162 TAS:ReactomePtoll-like receptor 9 signaling pathway
GO:0002224 TAS:ReactomePtoll-like receptor signaling pathway
GO:0038123 TAS:ReactomePtoll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS:ReactomePtoll-like receptor TLR6:TLR2 signaling pathway
GO:0006351 IEA:UniProtKB-KWPtranscription, DNA-templated
GO:0007178 IEA:EnsemblPtransmembrane receptor protein serine/threonine kinase signaling pathway
GO:0035666 TAS:ReactomePTRIF-dependent toll-like receptor signaling pathway
GO:0048010 IMP:BHF-UCLPvascular endothelial growth factor receptor signaling pathway
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_21399activated TAK1 mediates p38 MAPK activation
REACT_6890Activated TLR4 signalling
REACT_264544Activation of PPARGC1A (PGC-1alpha) by phosphorylation
REACT_21326Activation of the AP-1 family of transcription factors
REACT_19140ADP signalling through P2Y purinoceptor 1
REACT_21402CDO in myogenesis
REACT_111155Cell-Cell communication
REACT_120956Cellular responses to stress
REACT_169274Cellular Senescence
REACT_111045Developmental Biology
REACT_25299DSCAM interactions
REACT_12599ERK/MAPK targets
REACT_71Gene Expression
REACT_604Hemostasis
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_25042KSRP destabilizes mRNA
REACT_21308MAP kinase activation in TLR cascade
REACT_21328MAPK targets/ Nuclear events mediated by MAP kinases
REACT_264351Mitochondrial biogenesis
REACT_27215MyD88 cascade initiated on plasma membrane
REACT_25222MyD88 dependent cascade initiated on endosome
REACT_6809MyD88-independent cascade
REACT_6788MyD88:Mal cascade initiated on plasma membrane
REACT_21303Myogenesis
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_75776NOD1/2 Signaling Pathway
REACT_12433Nuclear Events (kinase and transcription factor activation)
REACT_75913Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
REACT_264135Organelle biogenesis and maintenance
REACT_169436Oxidative Stress Induced Senescence
REACT_12065p38MAPK events
REACT_798Platelet activation, signaling and aggregation
REACT_23876Platelet homeostasis
REACT_23879Platelet sensitization by LDL
REACT_24994Regulation of mRNA stability by proteins that bind AU-rich elements
REACT_20524Signal amplification
REACT_12529Signaling by VEGF
REACT_11061Signalling by NGF
REACT_12058Signalling to ERKs
REACT_12033Signalling to RAS
REACT_111102Signal Transduction
REACT_9027Toll Like Receptor 10 (TLR10) Cascade
REACT_7980Toll Like Receptor 2 (TLR2) Cascade
REACT_6783Toll Like Receptor 3 (TLR3) Cascade
REACT_6894Toll Like Receptor 4 (TLR4) Cascade
REACT_9061Toll Like Receptor 5 (TLR5) Cascade
REACT_9020Toll Like Receptor 7/8 (TLR7/8) Cascade
REACT_9047Toll Like Receptor 9 (TLR9) Cascade
REACT_6966Toll-Like Receptors Cascades
REACT_8005Toll Like Receptor TLR1:TLR2 Cascade
REACT_8006Toll Like Receptor TLR6:TLR2 Cascade
REACT_25024TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
REACT_25281TRIF-mediated TLR3/TLR4 signaling
REACT_264464VEGFA-VEGFR2 Pathway
SMP Pathway Links
SMP IDDescription
SMP00358Fc Epsilon Receptor I Signaling in Mast Cells
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