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MGP000705

UniProt Annotations

Entry Information
Gene Namecasein kinase 2, beta polypeptide
Protein EntryCSK2B_HUMAN
UniProt IDP67870
SpeciesHuman
Comments
Comment typeDescription
FunctionParticipates in Wnt signaling (By similarity). Plays a complex role in regulating the basal catalytic activity of the alpha subunit. {ECO:0000250, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:16818610}.
InteractionSelf; NbExp=7; IntAct=EBI-348169, EBI-348169; O00555:CACNA1A; NbExp=2; IntAct=EBI-348169, EBI-766279; O00257-3:CBX4; NbExp=2; IntAct=EBI-348169, EBI-4392727; Q9JK25:Clip1 (xeno); NbExp=2; IntAct=EBI-348169, EBI-908338; O08785:Clock (xeno); NbExp=2; IntAct=EBI-348169, EBI-79859; P68400:CSNK2A1; NbExp=13; IntAct=EBI-348169, EBI-347804; P19784:CSNK2A2; NbExp=6; IntAct=EBI-348169, EBI-347451; Q6VY07:PACS1; NbExp=3; IntAct=EBI-348169, EBI-2555014; Q96EB6:SIRT1; NbExp=5; IntAct=EBI-348169, EBI-1802965;
PtmPhosphorylated by alpha subunit. {ECO:0000269|PubMed:11574463, ECO:0000269|PubMed:18691976, ECO:0000269|PubMed:19369195, ECO:0000269|PubMed:20068231, ECO:0000269|PubMed:21406692, ECO:0000269|PubMed:2300566}.
Sequence CautionSequence=CAI18393.2; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the casein kinase 2 subunit beta family. {ECO:0000305}.
SubunitTetramer composed of an alpha subunit, an alpha' subunit and two beta subunits. The beta subunit dimerization is mediated by zinc ions. Interacts with TCTEX1D3 (By similarity). Interacts with CD163. Also component of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, the complex associating following UV irradiation. Interacts with MUSK; mediates phosphorylation of MUSK by CK2. Interacts with FGF1; this interaction is increased in the presence of FIBP, suggesting a possible cooperative interaction between CSNKB and FIBP in binding to FGF1. {ECO:0000250, ECO:0000269|PubMed:10357806, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:11298324, ECO:0000269|PubMed:11574463, ECO:0000269|PubMed:11964394, ECO:0000269|PubMed:12393879, ECO:0000269|PubMed:16818610}.
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