MGP Database

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MGP000833

UniProt Annotations

Entry Information
Gene Namedeiodinase, iodothyronine, type I
Protein EntryIOD1_HUMAN
UniProt IDP49895
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=9; Name=1; Synonyms=a; IsoId=P49895-1; Sequence=Displayed; Name=2; Synonyms=b; IsoId=P49895-2; Sequence=VSP_012774; Name=3; Synonyms=c/f; IsoId=P49895-3; Sequence=VSP_012777, VSP_012778; Note=The UGA codon in position 83 may either function as a selenocysteine codon or a translation termination codon.; Name=4; Synonyms=d; IsoId=P49895-4; Sequence=VSP_012781; Name=5; Synonyms=e; IsoId=P49895-5; Sequence=VSP_012783, VSP_012784; Name=6; Synonyms=k; IsoId=P49895-6; Sequence=VSP_012772, VSP_012773; Note=No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. The UGA codon in position 34 may either function as a selenocysteine codon or a translation termination codon.; Name=7; Synonyms=l; IsoId=P49895-7; Sequence=VSP_012782; Name=8; Synonyms=m; IsoId=P49895-8; Sequence=VSP_012775, VSP_012776; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. The UGA codon in position 59 may either function as a selenocysteine codon or a translation termination codon.; Name=9; Synonyms=s; IsoId=P49895-9; Sequence=VSP_012779, VSP_012780; Note=No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. The UGA codon in position 59 may either function as a selenocysteine codon or a translation termination codon.;
Catalytic Activity3,5,3'-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH(2). {ECO:0000255|PROSITE-ProRule:PRU10107}.
FunctionResponsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine). Plays a role in providing a source of plasma T3 by deiodination of T4 in peripheral tissues such as liver and kidney.
SimilarityBelongs to the iodothyronine deiodinase family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Web ResourceName=Wikipedia; Note=Deiodinase entry; URL="http://en.wikipedia.org/wiki/Deiodinase";
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