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MGP000880

Record overview

MGPD IDMGP000880
Gene ID1831
SpeciesHomo sapiens (Human)
Gene NameTSC22 domain family, member 3
Gene Symbol TSC22D3
SynonymsDIP; GILZ; hDIP; DSIPI; TSC-22R;
Alternate namesTSC22 domain family protein 3; TSC-22-like protein; TSC-22 related protein; TSC-22-related protein; DSIP-immunoreactive peptide; DSIP-immunoreactive leucine zipper protein; delta sleep-inducing peptide immunoreactor; delta sleep inducing peptide, immunoreactor; glucocorticoid-induced leucine zipper protein;
ChromosomeX
Map LocationXq22.3
SummaryThe protein encoded by this gene shares significant sequence identity with the murine TSC-22 and Drosophila shs, both of which are leucine zipper proteins, that function as transcriptional regulators. The expression of this gene is stimulated by glucocorticoids and interleukin 10, and it appears to play a key role in the anti-inflammatory and immunosuppressive effects of this steroid and chemokine. Transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for TSC22D3

Proteins

TSC22 domain family protein 3 isoform 1
Refseq ID:NP_932174
Protein GI:37622903
UniProt ID:Q99576
mRNA ID:NM_198057
Length:200
RefSeq Status:
MAQSKLDCRSPVGLDCCNCCLDLAHRSGLQRGSSGENNNPGSPTVSNFRQLQEKLVFENLNTDKLNSIMRQDSLEPVLRDPCYLINEGICNRNIDQTMLS
ILLFFHSASGASVVAIDNKIEQAMDLVKNHLMYAVREEVEILKEQIRELVEKNSQLERENTLLKTLASPEQLEKFQSCLSPEEPAPESPQVPEAPGGSAV
 
TSC22 domain family protein 3 isoform 2
Refseq ID:NP_004080
Protein GI:37622901
UniProt ID:Q99576
mRNA ID:NM_004089
Length:134
RefSeq Status:
MNTEMYQTPMEVAVYQLHNFSISFFSSLLGGDVVSVKLDNSASGASVVAIDNKIEQAMDLVKNHLMYAVREEVEILKEQIRELVEKNSQLERENTLLKTL
ASPEQLEKFQSCLSPEEPAPESPQVPEAPGGSAV
 
TSC22 domain family protein 3 isoform 3
Refseq ID:NP_001015881
Protein GI:62865625
UniProt ID:Q5JRJ2
mRNA ID:NM_001015881
Length:77
RefSeq Status:
MDLVKNHLMYAVREEVEILKEQIRELVEKNSQLERENTLLKTLASPEQLEKFQSCLSPEEPAPESPQVPEAPGGSAV
 
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