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MGP000920

Record overview

MGPD IDMGP000920
Gene ID1943
SpeciesHomo sapiens (Human)
Gene Nameephrin-A2
Gene Symbol EFNA2
SynonymsELF-1; EPLG6; LERK6; HEK7-L; LERK-6;
Alternate namesephrin-A2; HEK7 ligand; eph-related receptor tyrosine kinase ligand 6;
Chromosome19
Map Location19p13.3
SummaryThis gene encodes a member of the ephrin family. The protein is composed of a signal sequence, a receptor-binding region, a spacer region, and a hydrophobic region. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. Posttranslational modifications determine whether this protein localizes to the nucleus or the cytoplasm. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for EFNA2

Proteins

ephrin-A2 precursor
Refseq ID:NP_001396
Protein GI:27894381
UniProt ID:O43921
mRNA ID:NM_001405
Length:213
RefSeq Status:
MAPAQRPLLPLLLLLLPLPPPPFARAEDAARANSDRYAVYWNRSNPRFHAGAGDDGGGYTVEVSINDYLDIYCPHYGAPLPPAERMEHYVLYMVNGEGHA
SCDHRQRGFKRWECNRPAAPGGPLKFSEKFQLFTPFSLGFEFRPGHEYYYISATPPNAVDRPCLRLKVYVRPTNETLYEAPEPIFTSNNSCSSPGGCRLF
LSTIPVLWTLLGS
 
sig_peptide: 1..24
inference: non-experimental evidence, no additional details recorded
note: Potential; propagated from UniProtKB/Swiss-Prot (O43921.1)
calculated_mol_wt: 2589
peptide sequence: 
MAPAQRPLLPLLLLLLPLPPPPFA

mat_peptide: 25..188
product: Ephrin-A2
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (O43921.1)
calculated_mol_wt: 18716
peptide sequence: 
RAEDAARANSDRYAVYWNRSNPRFHAGAGDDGGGYTVEVSINDYLDIYCPHYGAPLPPAERMEHYVLYMVNGEGHASCDHRQRGFKRWECNRPAAPGGPL
KFSEKFQLFTPFSLGFEFRPGHEYYYISATPPNAVDRPCLRLKVYVRPTNETLYEAPEPIFTSN
 
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