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MGP000923

Record overview

MGPD IDMGP000923
Gene ID1946
SpeciesHomo sapiens (Human)
Gene Nameephrin-A5
Gene Symbol EFNA5
SynonymsAF1; EFL5; RAGS; EPLG7; GLC1M; LERK7;
Alternate namesephrin-A5; AL-1; LERK-7; eph-related receptor tyrosine kinase ligand 7;
Chromosome5
Map Location5q21
SummaryEphrin-A5, a member of the ephrin gene family, prevents axon bundling in cocultures of cortical neurons with astrocytes, a model of late stage nervous system development and differentiation. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. EPH receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin ligands and receptors have been named by the Eph Nomenclature Committee (1997). Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are similarly divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for EFNA5

Proteins

ephrin-A5 precursor
Refseq ID:NP_001953
Protein GI:4503487
UniProt ID:P52803
mRNA ID:NM_001962
Length:228
RefSeq Status:
MLHVEMLTLVFLVLWMCVFSQDPGSKAVADRYAVYWNSSNPRFQRGDYHIDVCINDYLDVFCPHYEDSVPEDKTERYVLYMVNFDGYSACDHTSKGFKRW
ECNRPHSPNGPLKFSEKFQLFTPFSLGFEFRPGREYFYISSAIPDNGRRSCLKLKVFVRPTNSCMKTIGVHDRVFDVNDKVENSLEPADDTVHESAEPSR
GENAAQTPRIPSRLLAILLFLLAMLLTL
 
sig_peptide: 1..20
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2412
peptide sequence: 
MLHVEMLTLVFLVLWMCVFS

mat_peptide: 21..228
product: ephrin-A5
calculated_mol_wt: 23903
peptide sequence: 
QDPGSKAVADRYAVYWNSSNPRFQRGDYHIDVCINDYLDVFCPHYEDSVPEDKTERYVLYMVNFDGYSACDHTSKGFKRWECNRPHSPNGPLKFSEKFQL
FTPFSLGFEFRPGREYFYISSAIPDNGRRSCLKLKVFVRPTNSCMKTIGVHDRVFDVNDKVENSLEPADDTVHESAEPSRGENAAQTPRIPSRLLAILLF
LLAMLLTL
 
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