MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP001083

Ontology/Pathway Information

Entrez Gene ID2280
Gene NameFK506 binding protein 1A, 12kDa
Gene Symbol FKBP1A
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:BHF-UCLCcytoplasm
GO:0005829 IDA:BHF-UCLCcytosol
GO:0005789 IBA:GO_CentralCendoplasmic reticulum membrane
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0016020 IDA:BHF-UCLCmembrane
GO:0014802 ISS:BHF-UCLCterminal cisterna
GO:0030018 IDA:BHF-UCLCZ disc
GO:0048185 IPI:BHF-UCLFactivin binding
GO:0005528 IDA:BHF-UCLFFK506 binding
GO:0044325 ISS:BHF-UCLFion channel binding
GO:0005527 NAS:BHF-UCLFmacrolide binding
GO:0003755 IDA:BHF-UCLFpeptidyl-prolyl cis-trans isomerase activity
GO:0004871 IMP:UniProtKBFsignal transducer activity
GO:0046332 IPI:BHF-UCLFSMAD binding
GO:0005160 ISS:BHF-UCLFtransforming growth factor beta receptor binding
GO:0034713 ISS:BHF-UCLFtype I transforming growth factor beta receptor binding
GO:1990000 IDA:BHF-UCLPamyloid fibril formation
GO:0070588 NAS:BHF-UCLPcalcium ion transmembrane transport
GO:0061077 IBA:GO_CentralPchaperone-mediated protein folding
GO:0006458 TAS:BHF-UCLP'de novo' protein folding
GO:0043206 IDA:BHF-UCLPextracellular fibril organization
GO:0003007 ISS:BHF-UCLPheart morphogenesis
GO:0060347 ISS:BHF-UCLPheart trabecula formation
GO:0032513 IDA:BHF-UCLPnegative regulation of protein phosphatase type 2B activity
GO:0043123 IMP:UniProtKBPpositive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0032092 IDA:BHF-UCLPpositive regulation of protein binding
GO:0031398 IDA:BHF-UCLPpositive regulation of protein ubiquitination
GO:0006457 NAS:UniProtKBPprotein folding
GO:0022417 TAS:BHF-UCLPprotein maturation by protein folding
GO:0000413 IDA:BHF-UCLPprotein peptidyl-prolyl isomerization
GO:0042026 TAS:BHF-UCLPprotein refolding
GO:0032925 IDA:BHF-UCLPregulation of activin receptor signaling pathway
GO:1902991 IGI:ParkinsonsUK-UCLPregulation of amyloid precursor protein catabolic process
GO:0050776 IMP:BHF-UCLPregulation of immune response
GO:0032880 IGI:ParkinsonsUK-UCLPregulation of protein localization
GO:0060314 IDA:BHF-UCLPregulation of ryanodine-sensitive calcium-release channel activity
GO:0007183 IDA:BHF-UCLPSMAD protein complex assembly
GO:0042110 NAS:BHF-UCLPT cell activation
GO:0007179 TAS:ReactomePtransforming growth factor beta receptor signaling pathway
GO:0055010 ISS:BHF-UCLPventricular cardiac muscle tissue morphogenesis
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_116125Disease
REACT_169398Loss of Function of SMAD2/3 in Cancer
REACT_169219Loss of Function of SMAD4 in Cancer
REACT_169311Loss of Function of TGFBR1 in Cancer
REACT_169435Loss of Function of TGFBR2 in Cancer
REACT_6844Signaling by TGF-beta Receptor Complex
REACT_169122Signaling by TGF-beta Receptor Complex in Cancer
REACT_111102Signal Transduction
REACT_169165SMAD2/3 MH2 Domain Mutants in Cancer
REACT_169103SMAD2/3 Phosphorylation Motif Mutants in Cancer
REACT_169107SMAD4 MH2 Domain Mutants in Cancer
REACT_120850TGF-beta receptor signaling activates SMADs
REACT_120726TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
REACT_169263TGFBR1 KD Mutants in Cancer
REACT_169445TGFBR1 LBD Mutants in Cancer
REACT_169440TGFBR2 Kinase Domain Mutants in Cancer
REACT_169192TGFBR2 MSI Frameshift Mutants in Cancer
  logo